The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

Hans Drenth; Johannes Hobbelen; Sytse U Zuidema; Ivan Bautmans

doi:10.1016/j.exger.2020.111125

The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

Vertaalde titel van de bijdrage: De rol van ontsteking en versuikerde eiwitten bij paratonie bij mensen met dementie

Hans Drenth (First author), Johannes Hobbelen, Sytse U Zuidema, Ivan Bautmans

University of Groningen, University Medical Center Groningen, Faculty of Medical Sciences, Department of General Practice, Geriatrics
Vrije Universiteit, Frailty in Aging Research Group and Gerontology Department

Onderzoeksoutput: Article › Academic › peer review

Samenvatting

Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.

Vertaalde titel van de bijdrage	De rol van ontsteking en versuikerde eiwitten bij paratonie bij mensen met dementie
Originele taal-2	English
Tijdschrift	Experimental Gerontology
Volume	142
Nummer van het tijdschrift	December
DOI's	https://doi.org/10.1016/j.exger.2020.111125
Status	Published - 22 okt. 2020

Keywords

paratonie
dementie
immunologie

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10.1016/j.exger.2020.111125Licentie: CC BY

Move in Age: International Joint Research Group 'Move in Age'
Hobbelen, H., Drenth, H., Zuidema, S. U. & Bautmans, I.
1/01/18 → …
Project: Research

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KW - immunologie

KW - gerontology

KW - dementia

KW - paratonia

KW - oxidative stress

KW - advanced glycation end products

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The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

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Keywords

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Projecten

Move in Age: International Joint Research Group 'Move in Age'

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