@article{86f50ab4c2474e15b372baa1204f28d1,
title = "The impact of goal disturbance after cancer on cortisol levels over time and the moderating role of COMT",
abstract = "Due to physical hindrance and time spent in hospital, a cancer diagnosis can lead to disturbance of personally important goals. Goal disturbance in cancer patients has been related to poorer psychological well-being. However, the relation with physiological measures is yet unknown. The purpose of the current study is to examine the impact of goal disturbance on cortisol as a measure of response to stress over time, and a possibly moderating role of a DNA genotype associated with HPA-axis functioning, Catechol-O-Methyl transferase (COMT).We examined the predictive value of goal disturbance on Cortisol Awakening Response (CAR) and Diurnal Cortisol Slope (DCS) over two periods: 1–7 and 7–18 months post-diagnosis, and the moderating role of COMT during these periods. Hierarchical regression analyses showed that goal disturbance 7 months post-diagnosis significantly predicted a steeper CAR a year later. During that period, the slow COMT variant moderated the relation, in that patients reporting high goal disturbance and had the Met/Met variant, had a more flattened CAR. No other significant effects were found. As steeper CARs have been related to adverse health outcomes, and COMT genotype may modify this risk, these results indicate that goal disturbance and genotype may be important factors to consider in maintaining better psychological and physical health in the already vulnerable population of cancer patients. (PsycInfo Database Record (c) 2022 APA, all rights reserved)",
keywords = "doelverstoring, Catechol-O-methyltransferase, kanker, cortisol niveaus, Op leeftijd, Circadiaans ritme, vrouwelijk, Genetische variatie, doelen, mensen, Hydrocortisone, mannelijk, Neoplasmata, Enzymen, Doelori{\"e}ntatie, welzijn, goal disturbance, Catechol-O-Methyl transferase, cancer, cortisol levels, Aged, Circadian Rhythm, Female, Genetic Variation, Goals, Humans, Hydrocortisone, Male, Neoplasms, Enzymes, Goal Orientation, well being",
author = "Moniek Janse and \{van Faassen\}, Martijn and Ido Kema and Ans Smink and Ranchor, \{Adelita V.\} and Joke Fleer and Sprangers, \{Mirjam A. G.\}",
note = "Accession Number: 2015-40370-001. PMID: 26313260 Partial author list: First Author \& Affiliation: Janse, Moniek; Department of Health Psychology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands,
[email protected]. Release Date: 20151005. Correction Date: 20221128. Publication Type: Journal (Journal), Peer Reviewed Journal (Peer Reviewed Journal). Format Covered: Electronic. Document Type: Journal Article. Language: English. Major Descriptor: Enzymes; Goal Orientation; Hydrocortisone; Neoplasms. Minor Descriptor: Well Being. Classification: Physical \& Somatic Disorders (3290). Population: Human (10); Male (30); Female (40). Location: Netherlands. Age Group: Adulthood (18 yrs \& older) (300); Aged (65 yrs \& older) (380). Tests \& Measures: Goal Disturbance Scale. Methodology: Empirical Study; Longitudinal Study; Interview; Quantitative Study. Supplemental Data: Data Sets Internet; Experimental Materials Internet. Page Count: 14. ArtID: e0135708. Issue Publication Date: Aug 27, 2015. Publication History: First Posted Date: Aug 27, 2015; Accepted Date: Jul 26, 2015; First Submitted Date: May 29, 2015. Copyright Statement: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Janse et al. 2015.",
year = "2015",
month = aug,
day = "27",
doi = "10.1371/journal.pone.0135708",
language = "Dutch",
volume = "10",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",
}