The Feasibility of Semi-Continuous and Multi-Frequency Thoracic Bioimpedance Measurements by a Wearable Device during Fluid Changes in Hemodialysis Patients

Melanie K Schoutteten, Lucas Lindeboom, Hélène De Cannière, Zoë Pieters, Liesbeth Bruckers, Astrid D H Brys, Patrick van der Heijden, Bart De Moor, Jacques Peeters, Chris Van Hoof, Willemijn Groenendaal, Jeroen P Kooman, Pieter M Vandervoort

Onderzoeksoutput: ArticleAcademicpeer review

Samenvatting

Repeated single-point measurements of thoracic bioimpedance at a single (low) frequency are strongly related to fluid changes during hemodialysis. Extension to semi-continuous measurements may provide longitudinal details in the time pattern of the bioimpedance signal, and multi-frequency measurements may add in-depth information on the distribution between intra- and extracellular fluid. This study aimed to investigate the feasibility of semi-continuous multi-frequency thoracic bioimpedance measurements by a wearable device in hemodialysis patients. Therefore, thoracic bioimpedance was recorded semi-continuously (i.e., every ten minutes) at nine frequencies (8–160 kHz) in 68 patients during two consecutive hemodialysis sessions, complemented by a single-point measurement at home in-between both sessions. On average, the resistance signals increased during both hemodialysis sessions and decreased during the interdialytic interval. The increase during dialysis was larger at 8 kHz (∆ 32.6 Ω during session 1 and ∆ 10 Ω during session 2), compared to 160 kHz (∆ 29.5 Ω during session 1 and ∆ 5.1 Ω during session 2). Whereas the resistance at 8 kHz showed a linear time pattern, the evolution of the resistance at 160 kHz was significantly different (p < 0.0001). Measuring bioimpedance semi-continuously and with a multi-frequency current is a major step forward in the understanding of fluid dynamics in hemodialysis patients. This study paves the road towards remote fluid monitoring.
Originele taal-2English
TijdschriftSensors
Volume24
Nummer van het tijdschrift6
DOI's
StatusPublished - 15 mrt. 2024
Extern gepubliceerdJa

Keywords

  • mensen
  • haalbaarheidsstudies
  • elektrische impedantie
  • nierdialyse
  • extracellulaire vloeistof
  • draagbare elektronische apparaten

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