Structural and kinetic studies on ligand binding in wild-type and active-site mutants of penicillin acylase

Keyphrases

• Ligand Binding 100%
• Penicillin Acylase 100%
• Phenylacetic Acid 100%
• Active Site mutant 100%
• Kinetic Study 100%
• High Affinity 50%
• Binding Site 33%
• Reorient 16%
• Condensation 16%
• Lactams 16%
• β-lactam Antibiotics 16%
• Nucleophile 16%
• Semi-synthetic 16%
• Phenylacetic Acid Derivatives 16%
• Weak Binding 16%
• Van Der Waals Interaction 16%
• Improved Properties 16%
• Fixed Position 16%
• Low Affinity 16%
• Open Conformation 16%
• Substrate Binding 16%
• Efficient Synthesis 16%
• X-ray Crystallography 16%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Ligand Binding 100%
• Active Site 100%
• Penicillin 100%
• Conformation 66%
• Binding Site 66%
• Enzyme 33%
• X-Ray Crystallography 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Van Der Waals Force 16%