SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

Christa Dijkhuizen; Patrick  Korthuis; Juliana F. Vilachã; Maaike Smelt; Anthonie van der Wekken; Anke van den Berg; Lyndsay Drayer

SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

Christa Dijkhuizen (First author)
, Patrick Korthuis
, Juliana F. Vilachã
, Maaike Smelt
, Anthonie van der Wekken
, Anke van den Berg
, Lyndsay Drayer

Biomolecules & Health

University of Groningen, Faculty of Science and Engineering, Molecular Dynamics — Groningen Biomolecular Sciences and Biotechnology
University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine
Rijksuniversiteit Groningen, Universitair Medisch Centrum Groningen, Afdeling Pathologie en Medische Biologie

Onderzoeksoutput: Abstract › Academic

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Originele taal-2	English
Aantal pagina's	2
Status	Published - 2023
Evenement	European Society for Medial Oncology 2023 Conference - Madrid, Spain Duur: 20 okt. 2023 → 24 okt. 2023

Conference

Conference	European Society for Medial Oncology 2023 Conference
Verkorte titel	ESMO2023
Land/Regio	Spain
Stad	Madrid
Periode	20/10/23 → 24/10/23

Duurzame ontwikkelingsdoelstellingen van de VN

Deze output draagt bij aan de volgende duurzame ontwikkelingsdoelstelling(en)

SDG 03 – Goede gezondheid en welzijn

Keywords

ROS1
BA F3-cellen
moleculaire dynamica simulatie
ROS1-remmers

Research Focus Areas Hanze University of Applied Sciences

Healthy Ageing

Research Focus Areas Research Centre or Centre of Expertise

Medical Diagnostics & Point of Care Testing
Healthcare & Biotechnology

Publinova thema's

Gezondheid

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Abstract ESMO Madrid 2023 C.O.DijkhuizenSubmitted manuscript, 234 KB

Citeer dit

@conference{3f4f52e9932a41238ba7a81afa238dac,

title = "SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume",

keywords = "ROS1, Ba/F3 cells, molecular dynamics simulation, ROS1 inhibitors, ROS1, BA F3-cellen, moleculaire dynamica simulatie, ROS1-remmers",

author = "Christa Dijkhuizen and Patrick Korthuis and Vilach{\~a}, \{Juliana F.\} and Maaike Smelt and \{van der Wekken\}, Anthonie and \{van den Berg\}, Anke and Lyndsay Drayer",

year = "2023",

language = "English",

note = "European Society for Medial Oncology 2023 Conference, ESMO2023 ; Conference date: 20-10-2023 Through 24-10-2023",

}

TY - CONF

T1 - SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

AU - Dijkhuizen, Christa

AU - Korthuis, Patrick

AU - Vilachã, Juliana F.

AU - Smelt, Maaike

AU - van der Wekken, Anthonie

AU - van den Berg, Anke

AU - Drayer, Lyndsay

PY - 2023

Y1 - 2023

KW - ROS1

KW - Ba/F3 cells

KW - molecular dynamics simulation

KW - ROS1 inhibitors

KW - ROS1

KW - BA F3-cellen

KW - moleculaire dynamica simulatie

KW - ROS1-remmers

M3 - Abstract

T2 - European Society for Medial Oncology 2023 Conference

Y2 - 20 October 2023 through 24 October 2023

ER -