@article{ef625647f17546f9936c7670b3195a54,
title = "Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation",
abstract = "Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA.Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.",
keywords = "atrial fibrillation, heat shock protein, drosophila, proteostasis, geranylgeranylacetone, hartaandoeningen",
author = "Andr{\'e} Heeres and Hu Xu and {van Marion}, {Denise MS} and Femke Hoogstra-Berends and Deli Zhang and Jean-Paul Seerden and Lizette Loen and Herman Steen and Henning, {Robert H} and Brundel, {Bianca J J M}",
year = "2019",
month = jan,
day = "18",
language = "English",
volume = "13",
pages = " 345—364 ",
journal = "Drug Design, Development and Therapy",
issn = "1177-8881",
publisher = "Dove Press Limited",
}