Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture

Kjeld J C van Bommel; Cornelia van der Pol; Inouk Muizebelt; Arianna Friggeri; André Heeres; Auke Meetsma; Ben L Feringa; Jan van Esch

doi:10.1002/anie.200352396

Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture

Kjeld J C van Bommel, Cornelia van der Pol, Inouk Muizebelt, Arianna Friggeri, André Heeres, Auke Meetsma, Ben L Feringa, Jan van Esch

Biobased Ingredients and Materials

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pH-sensitive gels: By using a cyclohexane-based scaffold to which various amino acid based substituents can be connected, low-molecular-weight compounds were obtained that can gelate water at very low concentrations. Their modular design (see picture: AA = amino acid(s), X = hydrophilic substituent, dark purple = hydrophobic region, light purple = hydrophilic region), allows tuning of the thermally and pH-induced reversible gel-to-sol transition of their gels.

Originele taal-2	English
Pagina's (van-tot)	1663-1667
Tijdschrift	Angewandte Chemie (International ed. in English)
Volume	43
Nummer van het tijdschrift	13
DOI's	https://doi.org/10.1002/anie.200352396
Status	Published - 19 mrt. 2004

Keywords

aminozuren

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10.1002/anie.200352396

1 Article

GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2
Heeres, A., van der Hoek, S., Antunes, I. F., Attia, K. A., Jacquet, O., Bulthuis, M., Zijlma, R., Boersma, H. H., van Goor, H., Visser, T. J., Heerspink, H. J. L., Elsinga, P. H. & Stevens, J., 8 nov. 2021, In: Journal of Medicinal Chemistry.
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title = "Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture",

abstract = "pH-sensitive gels: By using a cyclohexane-based scaffold to which various amino acid based substituents can be connected, low-molecular-weight compounds were obtained that can gelate water at very low concentrations. Their modular design (see picture: AA = amino acid(s), X = hydrophilic substituent, dark purple = hydrophobic region, light purple = hydrophilic region), allows tuning of the thermally and pH-induced reversible gel-to-sol transition of their gels.",

keywords = "crystallography, x-ray, cyclohexanes, hydrogels, hydrogen-ion concentration, models, molecular, molecular conformation, molecular weight, aminozuren",

author = "{van Bommel}, {Kjeld J C} and {van der Pol}, Cornelia and Inouk Muizebelt and Arianna Friggeri and Andr{\'e} Heeres and Auke Meetsma and Feringa, {Ben L} and {van Esch}, Jan",

year = "2004",

month = mar,

day = "19",

doi = "10.1002/anie.200352396",

language = "English",

volume = "43",

pages = "1663--1667",

journal = "Angewandte Chemie - International Edition",

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Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture. / van Bommel, Kjeld J C; van der Pol, Cornelia; Muizebelt, Inouk; Friggeri, Arianna; Heeres, André; Meetsma, Auke; Feringa, Ben L; van Esch, Jan.

In: Angewandte Chemie (International ed. in English), Vol. 43, Nr. 13, 19.03.2004, blz. 1663-1667.

Onderzoeksoutput: Article › Academic › peer review

TY - JOUR

T1 - Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture

AU - van Bommel, Kjeld J C

AU - van der Pol, Cornelia

AU - Muizebelt, Inouk

AU - Friggeri, Arianna

AU - Heeres, André

AU - Meetsma, Auke

AU - Feringa, Ben L

AU - van Esch, Jan

PY - 2004/3/19

Y1 - 2004/3/19

N2 - pH-sensitive gels: By using a cyclohexane-based scaffold to which various amino acid based substituents can be connected, low-molecular-weight compounds were obtained that can gelate water at very low concentrations. Their modular design (see picture: AA = amino acid(s), X = hydrophilic substituent, dark purple = hydrophobic region, light purple = hydrophilic region), allows tuning of the thermally and pH-induced reversible gel-to-sol transition of their gels.

AB - pH-sensitive gels: By using a cyclohexane-based scaffold to which various amino acid based substituents can be connected, low-molecular-weight compounds were obtained that can gelate water at very low concentrations. Their modular design (see picture: AA = amino acid(s), X = hydrophilic substituent, dark purple = hydrophobic region, light purple = hydrophilic region), allows tuning of the thermally and pH-induced reversible gel-to-sol transition of their gels.

KW - crystallography, x-ray

KW - cyclohexanes

KW - hydrogels

KW - hydrogen-ion concentration

KW - models, molecular

KW - molecular conformation

KW - molecular weight

KW - aminozuren

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DO - 10.1002/anie.200352396

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 13

ER -

Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture

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Keywords

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GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

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