pyPaSWAS: Python-based multi-core CPU and GPU sequence alignment

Vertaalde titel van de bijdrage: pyPaSWAS: Een op Python-gebaseerde multi-core CPU en GPU sequence aligner

Sven Warris, N Roshan N Timal, Marcel Kempenaar, Arne M Poortinga, Henri van de Geest, Ana L Varbanescu, Jan-Peter Nap

Onderzoeksoutput: ArticleAcademicpeer review


BACKGROUND: Our previously published CUDA-only application PaSWAS for Smith-Waterman (SW) sequence alignment of any type of sequence on NVIDIA-based GPUs is platform-specific and therefore adopted less than could be. The OpenCL language is supported more widely and allows use on a variety of hardware platforms. Moreover, there is a need to promote the adoption of parallel computing in bioinformatics by making its use and extension more simple through more and better application of high-level languages commonly used in bioinformatics, such as Python.

RESULTS: The novel application pyPaSWAS presents the parallel SW sequence alignment code fully packed in Python. It is a generic SW implementation running on several hardware platforms with multi-core systems and/or GPUs that provides accurate sequence alignments that also can be inspected for alignment details. Additionally, pyPaSWAS support the affine gap penalty. Python libraries are used for automated system configuration, I/O and logging. This way, the Python environment will stimulate further extension and use of pyPaSWAS.

CONCLUSIONS: pyPaSWAS presents an easy Python-based environment for accurate and retrievable parallel SW sequence alignments on GPUs and multi-core systems. The strategy of integrating Python with high-performance parallel compute languages to create a developer- and user-friendly environment should be considered for other computationally intensive bioinformatics algorithms.

Vertaalde titel van de bijdragepyPaSWAS: Een op Python-gebaseerde multi-core CPU en GPU sequence aligner
Originele taal-2English
Aantal pagina's9
TijdschriftPLoS ONE
Nummer van het tijdschrift1
StatusPublished - 1 jan. 2018


  • bioinformatica
  • software ontwikkeling


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