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Samenvatting
Methods: A total of 81 consecutive systemic sclerosis patients were included, 40 with systemic sclerosis pulmonary hypertension and 41 with no pulmonary hypertension. In each group, quantitative and qualitative nailfold capillaroscopy microscopy characteristics, vascular autoantibodies AT1R and ETAR, and serum levels of 24 soluble serum factors were determined. For evaluation of the nailfold capillaroscopy microscopy characteristics, linear regression analysis accounting for age, sex, and diffusing capacity of the lungs for carbon monoxide percentage predicted was used. Autoantibodies and soluble serum factor levels were compared using two-sample t test with equal variances.
Results: No statistically significant differences were observed in quantitative or qualitative nailfold capillaroscopy microscopy characteristics, or vascular autoantibody ETAR and AT1R titer between systemic sclerosis-pulmonary hypertension and systemic sclerosis-no pulmonary hypertension. In contrast, several serum levels of soluble factors differed between groups: Endostatin, sVCAM, and VEGFD were increased, and CXCL4, sVEGFR2, and PDGF-AB/BB were decreased in systemic sclerosis-pulmonary hypertension. Random forest classification identified Endostatin and CXCL4 as the most predictive classifiers to distinguish systemic sclerosispulmonary hypertension from systemic sclerosis-no pulmonary hypertension.
Conclusion: This study shows the potential for several soluble serum factors to distinguish systemic sclerosis-pulmonary hypertension from systemic sclerosis-no pulmonary hypertension. We found no classifying potential for qualitative or quantitative nailfold capillaroscopy microscopy characteristics, or vascular autoantibodies.
Originele taal-2 | English |
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Artikelnummer | 3 |
Pagina's (van-tot) | 221-230 |
Aantal pagina's | 9 |
Tijdschrift | Journal of Scleroderma and Related Disorders |
Volume | 8 |
Nummer van het tijdschrift | 3 |
DOI's | |
Status | E-pub ahead of print - 22 mei 2023 |
Keywords
- capillaroscopie van de nagelplooi
- kandidaat-biomarkers
- pulmonale arteriële hypertensie
- systemische sclerose
Vingerafdruk
Duik in de onderzoeksthema's van 'Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study'. Samen vormen ze een unieke vingerafdruk.-
CureQ Predict, Delay & Cure polyglutamine(Q) caused neurodegeneration
1/01/23 → 31/12/27
Project: Research
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Epi-Guide-Edit - Reprogramming by Epigenetic editing: A non-invasive, CRISPR approach to guide cell behavior
Alkema, W. & Smelt, M.
1/10/22 → 30/09/27
Project: Research
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Dynamisch/ecologisch modelleren van reeënpopulaties in Groningen en de relatie met afschot en aanrijdingen
Alkema, W., Wassenaar, T. & Noback, M.
1/03/22 → 31/08/22
Project: Research
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A proteomics approach to identify COPD-related changes in lung fibroblasts
Bekker, N. J., van Pijkeren, A., Wolters, J. C., Sánchez Brotons, A., Guryev, V., Woldhuis, R. R., Bischoff, R., Alkema, W., Horvatovich, P., van Nijnatten, J. L. L., van den Berge, M., Timens, W. & Brandsma, C-A., 1 apr. 2023, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 324, 4, blz. L521-L535Onderzoeksoutput: Article › Academic › peer review
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The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods
van Beuningen, N., Alkema, S., Hijlkema, N., Ulfhake, B., Frias, R., Ritskes-Hoitinga, M. & Alkema, W., 21 okt. 2023, In: Alternatives to Laboratory Animals. 51, 6, blz. 376-386 10 blz.Onderzoeksoutput: Article › Academic › peer review
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Autoantibody profiles in systemic sclerosis: a comparison of diagnostic tests
Alkema, W., Koenen, H. J. P. M., Kersten, B. E., Kaffa, C., Nannenberg-Koops, J. W. & Damoiseux, J. G. M. C., 5 apr. 2021, In: Autoimmunity. 54, 3, blz. 148-155 7 blz.Onderzoeksoutput: Article › Academic › peer review
Activiteiten
- 1 Oral presentation
Pers/Media
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Data-onderzoek legt patronen bloot in het belang van gezondheid
7/11/23
1 item van Media-aandacht
Pers / media: Expert Comment
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'Productontwikkelaars moeten zich verdiepen in de mogelijkheden van Artificial intelligence'
17/09/23
1 item van Media-aandacht
Pers / media: Expert Comment
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AI versnelt product ontwikkeling in de voedingsindustrie
Wynand Alkema & Fenna Feenstra
3/06/22
1 Mediabijdrage
Pers / media: Research