Molecular simulations explain the effects of the p.(L2026M+G2032R) double mutation in ROS1 on targeted TKI treatment

Christa Dijkhuizen; Patrick  Korthuis; Lyndsay Drayer; Margot De Looff; Fin Milder; Anke van den Berg; Anthonie van der Wekken; Tsjerk Wassenaar

Molecular simulations explain the effects of the p.(L2026M+G2032R) double mutation in ROS1 on targeted TKI treatment

Christa Dijkhuizen (First author)
, Patrick Korthuis
, Lyndsay Drayer
, Margot De Looff
, Fin Milder
, Anke van den Berg
, Anthonie van der Wekken
, Tsjerk Wassenaar

Biomolecules & Health

University of Groningen, University Medical Center Groningen, Department of Pulmonology
Rijksuniversiteit Groningen, Universitair Medisch Centrum Groningen, Afdeling Pathologie en Medische Biologie
University of Groningen, Faculty of Science and Engineering, Molecular Dynamics — Groningen Biomolecular Sciences and Biotechnology

Onderzoeksoutput: Abstract › Academic

Originele taal-2	English
Aantal pagina's	1
Status	Submitted - 26 aug. 2025
Evenement	EMBL Heidelberg EMBO Computational Structural Biology - Heidelberg, Germany Duur: 2 dec. 2025 → 5 dec. 2025

Conference

Conference	EMBL Heidelberg EMBO Computational Structural Biology
Verkorte titel	EMBL 2025
Land/Regio	Germany
Stad	Heidelberg
Periode	2/12/25 → 5/12/25

Keywords

ROS1-remmers
moleculaire dynamica simulatie
principale-componentenanalyse

Research Focus Areas Hanze University of Applied Sciences

Healthy Ageing

Research Focus Areas Research Centre or Centre of Expertise

Medical Diagnostics & Point of Care Testing
Healthcare & Biotechnology

Publinova thema's

Gezondheid

Citeer dit

@conference{26f90e3200db4910ab22d09ca468af57,

title = "Molecular simulations explain the effects of the p.(L2026M+G2032R) double mutation in ROS1 on targeted TKI treatment",

keywords = "ROS1-remmers, moleculaire dynamica simulatie, principale-componentenanalyse, ROS1, ROS1 inhibitors, molecular dynamics simulation, Principal Component Analysis",

author = "Christa Dijkhuizen and Patrick Korthuis and Lyndsay Drayer and \{De Looff\}, Margot and Fin Milder and \{van den Berg\}, Anke and \{van der Wekken\}, Anthonie and Tsjerk Wassenaar",

year = "2025",

month = aug,

day = "26",

language = "English",

note = "EMBL Heidelberg EMBO Computational Structural Biology ; Conference date: 02-12-2025 Through 05-12-2025",

}

TY - CONF

T1 - Molecular simulations explain the effects of the p.(L2026M+G2032R) double mutation in ROS1 on targeted TKI treatment

AU - Dijkhuizen, Christa

AU - Korthuis, Patrick

AU - Drayer, Lyndsay

AU - De Looff, Margot

AU - Milder, Fin

AU - van den Berg, Anke

AU - van der Wekken, Anthonie

AU - Wassenaar, Tsjerk

PY - 2025/8/26

Y1 - 2025/8/26

KW - ROS1-remmers

KW - moleculaire dynamica simulatie

KW - principale-componentenanalyse

KW - ROS1

KW - ROS1 inhibitors

KW - molecular dynamics simulation

KW - Principal Component Analysis

M3 - Abstract

T2 - EMBL Heidelberg EMBO Computational Structural Biology

Y2 - 2 December 2025 through 5 December 2025

ER -