Lack of prognostic value of type D personality for mortality in a large sample of heart failure patients

James C Coyne, Tiny Jaarsma, Marie-Louise Luttik, Eric van Sonderen, Dirk J van Veldhuisen, Robbert Sanderman

Onderzoeksoutput: ArticleAcademicpeer review

Samenvatting

BACKGROUND: Type D personality has been proposed as a prognostic indicator for mortality in cardiovascular disease. Most research examining this construct originates from one research group, and it is critical that the predictive value of Type D personality for adverse outcomes is independently cross-validated. This study examined its prognostic value in heart failure, relative to B-type natriuretic peptide (BNP) and depressive symptoms.

METHODS: We studied 706 patients with complete BNP, depressive symptom, and Type D personality and mortality data from 958 patients with heart failure enrolled after hospitalization for a multisite study of a disease management program. Multivariable models were adjusted for BNP and depression.

RESULTS: At 18 months, there were 192 deaths (27.2%). No evidence was found for a prognostic value of Type D personality in the unadjusted model (hazard ratio [HR] = 0.893, 95% confidence interval [CI] = 0.582-1.370). In contrast, BNP was significantly predictive of mortality (HR = 1.588, 95% CI = 1.391-1.812), whereas depression was not (HR = 1.011, 95% CI = 0.998-1.024). Type D was also not predictive in covariate-adjusted models (HR = 0.779, 95% CI = 0.489-1.242). Similar results were obtained when analyzing Type D as the interaction between continuous z scores of its two components, negative affectivity and social inhibition (p = .144).

CONCLUSIONS: In the largest study to date, Type D does not predict mortality. Future research should construe Type D as the interaction of continuous negative affectivity and social inhibition z scores, rather than as a typology, and consider analyses replacing negative affectivity with depression.

Originele taal-2English
Pagina's (van-tot)557-562
TijdschriftPsychosomatic Medicine
Volume73
Nummer van het tijdschrift7
DOI's
StatusPublished - 1 sep. 2011
Extern gepubliceerdJa

Keywords

  • depressies
  • hartfalen

Vingerafdruk

Duik in de onderzoeksthema's van 'Lack of prognostic value of type D personality for mortality in a large sample of heart failure patients'. Samen vormen ze een unieke vingerafdruk.

Citeer dit