Fast selection of miRNA candidates based on large-scale pre-computed MFE sets of randomized sequences.

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Small RNAs are important regulators of genome function, yet their prediction in genomes is still a major computational challenge. Statistical analyses of pre-miRNA sequences indicated that their 2D structure tends to have a minimal free energy (MFE) significantly lower than MFE values of equivalently randomized sequences with the same nucleotide composition, in contrast to other classes of non-coding RNA. The computation of many MFEs is, however, too intensive to allow for genome-wide screenings.
Originele taal-2English
Aantal pagina's10
TijdschriftBMC research notes
StatusPublished - 13 jan 2014

Keywords

  • moleculaire technieken

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