Effect of positive expiratory pressure breathing in patients with cystic fibrosis

Cees van der Schans, T W van der Mark, G de Vries, D A Piers, H Beekhuis, J E Dankert-Roelse, D S Postma, G H Koëter

Onderzoeksoutput: ArticleAcademicpeer review

Uittreksel

The effect of positive expiratory pressure breathing, alone and in combination with coughing, was investigated in eight patients with cystic fibrosis. Functional residual capacity and total lung capacity was measured with a body plethysmograph before, during, and immediately after breathing with expiratory pressure of 5 and 15 cm H2O, and after a coughing period. The positive expiratory pressure breathing was carried out five times for two minutes with a two minute interval between each period. Mucus transport was measured in a peripheral lung region and over the whole lung by a radioactive aerosol tracer technique. Clearance measurements were carried out continuously during positive expiratory pressure breathing and during a control period. Two minutes' breathing with an expiratory pressure of 5 and 15 cm H2O caused an increase in mean (SEM) functional residual capacity from 2.6 (0.1) to 3.6 (0.3) and 4.4 (0.5) 1 and an increase in total lung capacity from 5.1 (0.2) to 5.9 (0.3) and 6.9 (0.4) 1. Lung volumes were higher during breathing with an expiratory pressure of 15 cm H2O than with 5 cm H2O; both returned to baseline values immediately after positive expiratory pressure breathing. Spontaneous mucus clearance and mucus clearance by coughing were not influenced by positive expiratory pressure breathing at either expiratory pressure. Thus in patients with cystic fibrosis positive expiratory pressure breathing increases lung volumes in relation to the expiratory pressure imposed; these changes in lung volume did not, however, lead to an improvement of mucus transport.

Originele taal-2English
Pagina's (van-tot)252-256
TijdschriftThorax
Volume46
Nummer van het tijdschrift4
StatusPublished - apr 1991
Extern gepubliceerdJa

Keywords

  • hoest
  • cystic fibrosis
  • slijm

Citeer dit

van der Schans, C., van der Mark, T. W., de Vries, G., Piers, D. A., Beekhuis, H., Dankert-Roelse, J. E., ... Koëter, G. H. (1991). Effect of positive expiratory pressure breathing in patients with cystic fibrosis. Thorax, 46(4), 252-256.
van der Schans, Cees ; van der Mark, T W ; de Vries, G ; Piers, D A ; Beekhuis, H ; Dankert-Roelse, J E ; Postma, D S ; Koëter, G H. / Effect of positive expiratory pressure breathing in patients with cystic fibrosis. In: Thorax. 1991 ; Vol. 46, Nr. 4. blz. 252-256.
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abstract = "The effect of positive expiratory pressure breathing, alone and in combination with coughing, was investigated in eight patients with cystic fibrosis. Functional residual capacity and total lung capacity was measured with a body plethysmograph before, during, and immediately after breathing with expiratory pressure of 5 and 15 cm H2O, and after a coughing period. The positive expiratory pressure breathing was carried out five times for two minutes with a two minute interval between each period. Mucus transport was measured in a peripheral lung region and over the whole lung by a radioactive aerosol tracer technique. Clearance measurements were carried out continuously during positive expiratory pressure breathing and during a control period. Two minutes' breathing with an expiratory pressure of 5 and 15 cm H2O caused an increase in mean (SEM) functional residual capacity from 2.6 (0.1) to 3.6 (0.3) and 4.4 (0.5) 1 and an increase in total lung capacity from 5.1 (0.2) to 5.9 (0.3) and 6.9 (0.4) 1. Lung volumes were higher during breathing with an expiratory pressure of 15 cm H2O than with 5 cm H2O; both returned to baseline values immediately after positive expiratory pressure breathing. Spontaneous mucus clearance and mucus clearance by coughing were not influenced by positive expiratory pressure breathing at either expiratory pressure. Thus in patients with cystic fibrosis positive expiratory pressure breathing increases lung volumes in relation to the expiratory pressure imposed; these changes in lung volume did not, however, lead to an improvement of mucus transport.",
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van der Schans, C, van der Mark, TW, de Vries, G, Piers, DA, Beekhuis, H, Dankert-Roelse, JE, Postma, DS & Koëter, GH 1991, 'Effect of positive expiratory pressure breathing in patients with cystic fibrosis' Thorax, vol. 46, nr. 4, blz. 252-256.

Effect of positive expiratory pressure breathing in patients with cystic fibrosis. / van der Schans, Cees; van der Mark, T W; de Vries, G; Piers, D A; Beekhuis, H; Dankert-Roelse, J E; Postma, D S; Koëter, G H.

In: Thorax, Vol. 46, Nr. 4, 04.1991, blz. 252-256.

Onderzoeksoutput: ArticleAcademicpeer review

TY - JOUR

T1 - Effect of positive expiratory pressure breathing in patients with cystic fibrosis

AU - van der Schans, Cees

AU - van der Mark, T W

AU - de Vries, G

AU - Piers, D A

AU - Beekhuis, H

AU - Dankert-Roelse, J E

AU - Postma, D S

AU - Koëter, G H

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N2 - The effect of positive expiratory pressure breathing, alone and in combination with coughing, was investigated in eight patients with cystic fibrosis. Functional residual capacity and total lung capacity was measured with a body plethysmograph before, during, and immediately after breathing with expiratory pressure of 5 and 15 cm H2O, and after a coughing period. The positive expiratory pressure breathing was carried out five times for two minutes with a two minute interval between each period. Mucus transport was measured in a peripheral lung region and over the whole lung by a radioactive aerosol tracer technique. Clearance measurements were carried out continuously during positive expiratory pressure breathing and during a control period. Two minutes' breathing with an expiratory pressure of 5 and 15 cm H2O caused an increase in mean (SEM) functional residual capacity from 2.6 (0.1) to 3.6 (0.3) and 4.4 (0.5) 1 and an increase in total lung capacity from 5.1 (0.2) to 5.9 (0.3) and 6.9 (0.4) 1. Lung volumes were higher during breathing with an expiratory pressure of 15 cm H2O than with 5 cm H2O; both returned to baseline values immediately after positive expiratory pressure breathing. Spontaneous mucus clearance and mucus clearance by coughing were not influenced by positive expiratory pressure breathing at either expiratory pressure. Thus in patients with cystic fibrosis positive expiratory pressure breathing increases lung volumes in relation to the expiratory pressure imposed; these changes in lung volume did not, however, lead to an improvement of mucus transport.

AB - The effect of positive expiratory pressure breathing, alone and in combination with coughing, was investigated in eight patients with cystic fibrosis. Functional residual capacity and total lung capacity was measured with a body plethysmograph before, during, and immediately after breathing with expiratory pressure of 5 and 15 cm H2O, and after a coughing period. The positive expiratory pressure breathing was carried out five times for two minutes with a two minute interval between each period. Mucus transport was measured in a peripheral lung region and over the whole lung by a radioactive aerosol tracer technique. Clearance measurements were carried out continuously during positive expiratory pressure breathing and during a control period. Two minutes' breathing with an expiratory pressure of 5 and 15 cm H2O caused an increase in mean (SEM) functional residual capacity from 2.6 (0.1) to 3.6 (0.3) and 4.4 (0.5) 1 and an increase in total lung capacity from 5.1 (0.2) to 5.9 (0.3) and 6.9 (0.4) 1. Lung volumes were higher during breathing with an expiratory pressure of 15 cm H2O than with 5 cm H2O; both returned to baseline values immediately after positive expiratory pressure breathing. Spontaneous mucus clearance and mucus clearance by coughing were not influenced by positive expiratory pressure breathing at either expiratory pressure. Thus in patients with cystic fibrosis positive expiratory pressure breathing increases lung volumes in relation to the expiratory pressure imposed; these changes in lung volume did not, however, lead to an improvement of mucus transport.

KW - cystic fibrosis

KW - mucociliary clearance

KW - mucus

KW - hoest

KW - cystic fibrosis

KW - slijm

M3 - Article

VL - 46

SP - 252

EP - 256

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 4

ER -

van der Schans C, van der Mark TW, de Vries G, Piers DA, Beekhuis H, Dankert-Roelse JE et al. Effect of positive expiratory pressure breathing in patients with cystic fibrosis. Thorax. 1991 apr;46(4):252-256.