Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications

Alexander Laarman; Fin Milder; Jos van Strijp; Suzan Rooijakkers

doi:10.1007/s00109-009-0572-y

Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications

Alexander Laarman, Fin Milder, Jos van Strijp, Suzan Rooijakkers

Onderzoeksoutput: Review article › peer review

Samenvatting

The plasma proteins of the complement system are essential in the innate immune response against bacteria. Complement labels bacteria with opsonins to support phagocytosis and generates chemoattractants to attract phagocytes to the site of infection. In turn, bacterial human pathogens have evolved different strategies to specifically impair the complement response. Here, we review the large arsenal of complement inhibitors produced by the gram-positive pathogens Staphylococcus aureus and Group A Streptococcus. We discuss how these bacterial molecules provide us with new tools to treat both infectious and inflammatory disease conditions in humans.

Originele taal-2	English
Pagina's (van-tot)	115-20
Aantal pagina's	6
Tijdschrift	Journal of molecular medicine (Berlin, Germany)
Volume	88
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1007/s00109-009-0572-y
Status	Published - 9 jan. 2010
Extern gepubliceerd	Ja

Keywords

bacteriële eiwitten/genetica
complementactivatie/immunologie
grampositieve bacteriën/genetica
immuunontwijking
mensen
stafylokokkeninfecties/medicamenteuze behandeling
staphylococcus aureus/genetica
streptococcus pyogenes/genetica
streptokokkeninfecties/medicamenteuze behandeling

Toegang tot document

10.1007/s00109-009-0572-yLicentie: CC BY-NC

Citeer dit

@article{6dd82098031043e1a840ceb72a5bc94f,

title = "Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications",

abstract = "The plasma proteins of the complement system are essential in the innate immune response against bacteria. Complement labels bacteria with opsonins to support phagocytosis and generates chemoattractants to attract phagocytes to the site of infection. In turn, bacterial human pathogens have evolved different strategies to specifically impair the complement response. Here, we review the large arsenal of complement inhibitors produced by the gram-positive pathogens Staphylococcus aureus and Group A Streptococcus. We discuss how these bacterial molecules provide us with new tools to treat both infectious and inflammatory disease conditions in humans.",

keywords = "bacterial proteins/genetics, complement activation/immunology, gram-positive bacteria/genetics, humans, immune evasion, staphylococcal infections/drug therapy, staphylococcus aureus/genetics, streptococcal infections/drug therapy, streptococcus pyogenes/genetics, bacteri{\"e}le eiwitten/genetica, complementactivatie/immunologie, grampositieve bacteri{\"e}n/genetica, immuunontwijking, mensen, stafylokokkeninfecties/medicamenteuze behandeling, staphylococcus aureus/genetica, streptococcus pyogenes/genetica, streptokokkeninfecties/medicamenteuze behandeling",

author = "Alexander Laarman and Fin Milder and {van Strijp}, Jos and Suzan Rooijakkers",

year = "2010",

month = jan,

day = "9",

doi = "10.1007/s00109-009-0572-y",

language = "English",

volume = "88",

pages = "115--20",

journal = "Journal of molecular medicine (Berlin, Germany)",

issn = "0946-2716",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Complement inhibition by gram-positive pathogens

T2 - molecular mechanisms and therapeutic implications

AU - Laarman, Alexander

AU - Milder, Fin

AU - van Strijp, Jos

AU - Rooijakkers, Suzan

PY - 2010/1/9

Y1 - 2010/1/9

N2 - The plasma proteins of the complement system are essential in the innate immune response against bacteria. Complement labels bacteria with opsonins to support phagocytosis and generates chemoattractants to attract phagocytes to the site of infection. In turn, bacterial human pathogens have evolved different strategies to specifically impair the complement response. Here, we review the large arsenal of complement inhibitors produced by the gram-positive pathogens Staphylococcus aureus and Group A Streptococcus. We discuss how these bacterial molecules provide us with new tools to treat both infectious and inflammatory disease conditions in humans.

AB - The plasma proteins of the complement system are essential in the innate immune response against bacteria. Complement labels bacteria with opsonins to support phagocytosis and generates chemoattractants to attract phagocytes to the site of infection. In turn, bacterial human pathogens have evolved different strategies to specifically impair the complement response. Here, we review the large arsenal of complement inhibitors produced by the gram-positive pathogens Staphylococcus aureus and Group A Streptococcus. We discuss how these bacterial molecules provide us with new tools to treat both infectious and inflammatory disease conditions in humans.

KW - bacterial proteins/genetics

KW - complement activation/immunology

KW - gram-positive bacteria/genetics

KW - humans

KW - immune evasion

KW - staphylococcal infections/drug therapy

KW - staphylococcus aureus/genetics

KW - streptococcal infections/drug therapy

KW - streptococcus pyogenes/genetics

KW - bacteriële eiwitten/genetica

KW - complementactivatie/immunologie

KW - grampositieve bacteriën/genetica

KW - immuunontwijking

KW - mensen

KW - stafylokokkeninfecties/medicamenteuze behandeling

KW - staphylococcus aureus/genetica

KW - streptococcus pyogenes/genetica

KW - streptokokkeninfecties/medicamenteuze behandeling

U2 - 10.1007/s00109-009-0572-y

DO - 10.1007/s00109-009-0572-y

M3 - Review article

C2 - 20062962

SN - 0946-2716

VL - 88

SP - 115

EP - 120

JO - Journal of molecular medicine (Berlin, Germany)

JF - Journal of molecular medicine (Berlin, Germany)

IS - 2

ER -

Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications

Samenvatting

Keywords

Toegang tot document

Vingerafdruk

Citeer dit