Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form

Carlos A. Martinez, Renzo Meijer, Gerard Metselaar, Gerlof Kruithof, Curtis Moore, Pei Pei Kung, Erik Keller

Onderzoeksoutput: ArticleAcademicpeer review

Samenvatting

An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. The described synthesis was used to manufacture 6 kg of the title compound and can also be employed to produce the corresponding (1R)-enantiomer. © 2010 Elsevier Ltd. All rights reserved.
Originele taal-2English
Pagina's (van-tot)2408-2413
TijdschriftTetrahedron: asymmetry
Volume21
Nummer van het tijdschrift19
DOI's
StatusPublished - 7 okt 2010

Keywords

  • biotransformatie
  • biocatalisatie

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