Biobased Ingredients and Materials

2023

3D-geprint voedsel

Oudhuis, L., 7 dec. 2023, In: Food & Agribusiness. blz. 5 1 blz.

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A proteomics approach to identify COPD-related changes in lung fibroblasts

Bekker, N. J., van Pijkeren, A., Wolters, J. C., Sánchez Brotons, A., Guryev, V., Woldhuis, R. R., Bischoff, R., Alkema, W., Horvatovich, P., van Nijnatten, J. L. L., van den Berge, M., Timens, W. & Brandsma, C-A., 1 apr. 2023, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 324, 4, blz. L521-L535

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Dietitians’ preferences for plant-based energy and protein enriched products for treatment of (risk of) malnutrition: A prove study

MONDAY & Odé, C., dec. 2023, In: Clinical Nutrition ESPEN. 58, blz. 577-578 2 blz.

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Feasibility Study to Assess Canagliflozin Distribution and Sodium-Glucose Co-Transporter 2 Occupancy Using [18F]Canagliflozin in Patients with Type 2 Diabetes

van der Hoek, S., Willemsen, A. T. M., Visser, T., Heeres, A., Mulder, D. J., Bokkers, R. P. H., Slart, R. H. J. A., Elsinga, P. H., Heerspink, H. J. L. & Stevens, J., 10 mrt. 2023, In: Clinical Pharmacology and Therapeutics. 113, 6, blz. 1295-1303 9 blz.

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Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study

Lemmers, J., van Caam, A., Kersten, B. E., van den Ende, C., Knaapen, H., van Dijk, A., Hagmolen of Ten Have, W., van den Hoogen, F., Koenen, H. J. P. M., van Leuven, S., Alkema, W., Smeets, R. L. & Vonk, M. C., 22 mei 2023, (E-pub ahead of print) In: Journal of Scleroderma and Related Disorders. 8, 3, blz. 221-230 9 blz., 3.

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Substituted anilides from chitin-based 3-acetamido-furfural

van der Loo, C., Kaniraj, J. P., Wang, T., Pouwer, K., Broekman, O., Borst, M., Heeres, A., Deuss, P. & Minnaard, A., 5 okt. 2023, In: Organic and Biomolecular Chemistry. 21, 41, blz. 8372-8378 7 blz.

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The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods

van Beuningen, N., Alkema, S., Hijlkema, N., Ulfhake, B., Frias, R., Ritskes-Hoitinga, M. & Alkema, W., 21 okt. 2023, In: Alternatives to Laboratory Animals. 51, 6, blz. 376-386 10 blz.

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2022

Advantages of Producing Aromatics from Propene over Ethene Using Zeolite-Based Catalysts

Butolia, P. S., Xi, X., Winkelman, J. G. M., Stuart, M. C. A., van Akker, M., Heeres, A., Heeres, H. J. & Xie, J., 11 okt. 2022, In: Chemie Ingenieur Technik - CIT. 94, 11, blz. 1845-1852 8 blz.

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A time- and space-resolved catalyst deactivation study on the conversion of glycerol to aromatics using H-ZSM-5

He, S., Goldhoorn, H. R., Tegudeer, Z., Chandel, A., Heeres, A., Stuart, M. C. A. & Heeres, H. J., 15 apr. 2022, In: Chemical Engineering Journal. 434, 134620.

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Improved catalyst formulations for the conversion of glycerol to bio-based aromatics

He, S., Kramer, T. S., Klein, F. G. H., Chandel, A., Tegudeer, Z., Heeres, A., Liu, C., Pidko, E. & Heeres, H. J., 5 jan. 2022, In: Applied Catalysis A: General. 629

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Studying Telmisartan Plasma Exposure, Kidney Distribution, Receptor Occupancy, and Response in Patients With Type 2 Diabetes Using [11C]Telmisartan

van der Hoek, S., Mulder, D. J., T.M. Willemsen, A., Visser, T. J., Heeres, A., Slart, R. H. J. A., Elsinga, P. H., Heerspink, H. J. L. & Stevens, J., 7 sep. 2022, In: Clinical Pharmacology & Therapeutics. 112, 6, blz. 1264-1270 7 blz.

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2021

Autoantibody profiles in systemic sclerosis: a comparison of diagnostic tests

Alkema, W., Koenen, H. J. P. M., Kersten, B. E., Kaffa, C., Nannenberg-Koops, J. W. & Damoiseux, J. G. M. C., 5 apr. 2021, In: Autoimmunity. 54, 3, blz. 148-155 7 blz.

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Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients

Alkema, W., He, X., Kaffa, C., Joosten, I., Smeets, R. L., Koenen, H. J. P. M., Mulder, M. L. M., van den Reek, J. M. P. A., Urbano, P. C. M., Wang, X., van Cranenbroek, B., van Rijssen, E., Van Den Hoogen, F. H. J., de Jong, E. M. G. . J. & Wenink, M. H., 12 okt. 2021, In: International Journal of Molecular Sciences. 22, 10 blz., 10990.

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Catalytic Conversion of Free Fatty Acids to Bio-Based Aromatics: A Model Investigation Using Oleic Acid and an H-ZSM-5/Al2O3 Catalyst

He, S., Hiltje Klein, F. G., Kramer, T. S., Chandel, A., Tegudeer, Z., Heeres, A. & Heeres, H. J., 10 jan. 2021, In: ACS Sustainable Chemistry and Engineering. 9, 3, blz. 1128-1141 14 blz.

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Catalytic conversion of glycerol and co-feeds (fatty acids, alcohols, and alkanes) to bio-based aromatics: remarkable and unprecedented synergetic effects on catalyst performance

He, S., Kramer, T. S., Sukmayanda Santosa, D., Heeres, A. & Heeres, H. J., 18 dec. 2021, In: Green Chemistry. 24, 2, blz. 941-949 9 blz.

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Catalytic conversion of glycerol to bio-based aromatics using H-ZSM-5 in combination with various binders

He, S., Goldhoorn, H. R., Tegudeer, Z., Chandel, A., Heeres, A., Liu, C., Pidko, E. & Heeres, H. J., okt. 2021, In: Fuel Processing Technology. 221, 106944.

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GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

van der Hoek, S., Antunes, I. F., Attia, K. A., Jacquet, O., Heeres, A., Bulthuis, M., Zijlma, R., Boersma, H. H., van Goor, H., Visser, T. J., Heerspink, H. J. L., Elsinga, P. H. & Stevens, J., 8 nov. 2021, In: Journal of Medicinal Chemistry. 64, 22, blz. 16641–16649 9 blz.

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GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Heeres, A., van der Hoek, S., Antunes, I. F., Attia, K. A., Jacquet, O., Bulthuis, M., Zijlma, R., Boersma, H. H., van Goor, H., Visser, T. J., Heerspink, H. J. L., Elsinga, P. H. & Stevens, J., 8 nov. 2021, In: Journal of Medicinal Chemistry.

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The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature

Ritskes-Hoitinga, M. & Alkema, W., 28 sep. 2021, (E-pub ahead of print) In: ATLA Alternatives to Laboratory Animals. 49, 4, blz. 133-136 4 blz.

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Training in Collecting, Appraising and Synthesising Evidence for EFSA scientific assessments

de Vries, R., van Luijk, J., Hooijmans, C., Wever, K., Hoffmann, S., in ’t Hout, J., Langendam, M., Tillema, A., Alkema, W. & Ritskes‐Hoitinga, M., 6 jul. 2021, (E-pub ahead of print) In: EFSA Supporting Publications. 18, 7

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2020

Catalytic conversion of pure glycerol over an un-modified H-ZSM-5 zeolite to bio-based aromatics

Heeres, A., He, S., Zuur, K., Sukmayanda Santosa, D., Liu, C., Pidko, E. & Heeres, H. J., sep. 2020, (E-pub ahead of print) In: Applied Catalysis B: Environment and Energy. 281, 14 blz.

Onderzoeksoutput: Article › Academic › peer review

Diagnostic profiles for precision medicine in systemic sclerosis: stepping forward from single biomarkers towards pathophysiological panels

Smeets, R. L., Kersten, B. E., Joosten, I., Kaffa, C., Alkema, W., Koenen, H. J. P. M. & Vonk, M. C., 1 mei 2020, In: Autoimmunity reviews . 19, 5, 102515.

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Magnesium prevents vascular calcification in Klotho deficiency

Alkema, W., 1 mrt. 2020, In: Kidney International . 97, 3, blz. 487–501

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Revealing new leads for the impact of galacto-oligosaccharides on gut commensals and gut health benefits through text mining

Sijbers, A. M., Schoemaker, R. J. W., Nauta, A. & Alkema, W., 17 apr. 2020, In: Beneficial microbes. 11, 3, blz. 283-302

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2019

An improved catalytic pyrolysis concept for renewable aromatics from biomass involving a recycling strategy for co-produced polycyclic aromatic hydrocarbons†

Heeres, A., Heeres, H. J., Schenk, N., Genuino, H., Muizebelt, I. & Winkelman, J., 25 jun. 2019, In: Green Chemistry. blz. 3802–3806 21.

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Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Heeres, A., Xu, H., van Marion, D. MS., Hoogstra-Berends, F., Zhang, D., Seerden, J-P., Loen, L., Steen, H., Henning, R. H. & Brundel, B. J. J. M., 18 jan. 2019, In: Drug Design, Development and Therapy. 13, blz. 345—364

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2018

Synthesis of Bio-aromatics from Black Liquors Using Catalytic Pyrolysis

Heeres, A., Schenk, N., Muizebelt, I., Blees, R., De Waele, B., Zeeuw, A-J., Meyer, N., Carr, R., Wilbers, E. & Heeres, H. J., 5 mrt. 2018, In: ACS sustainable chemistry & engineering. 6, 3, blz. 3472-3480 9 blz.

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2017

Rapid chemoenzymatic route to glutamate transporter inhibitor l -TFB-TBOA and related amino acids

Fu, H., Younes, S. H. H., Saifuddin, M., Tepper, P. G., Zhang, J., Keller, E., Heeres, A., Szymanski, W. & Poelarends, G. J., 2017, In: Organic & biomolecular chemistry. 15, 11, blz. 2341-2344

Onderzoeksoutput: Article › Academic › peer review

2015

The structure of wheat bread influences the postprandial metabolic response in healthy men

Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, J. J., Deacon, C. F., Rehfeld, J. F., Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 7 aug. 2015, In: Food and Function. 6, 10, blz. 3236-3248 13 blz.

Onderzoeksoutput: Article › Academic › peer review

2014

Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress

Dijkstra, A. R., Setyawati, M. C., Bayjanov, J. R., Alkema, W., van Hijum, S. A. F. T., Bron, P. A. & Hugenholtz, J., 15 jan. 2014, In: Applied and Environmental Microbiology. 80, 2, blz. 603-611 9 blz.

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2013

Genotypic adaptations associated with prolonged persistence of Lactobacillus plantarum in the murine digestive tract

van Bokhorst-van de Veen, H., Smelt, M. J., Wels, M., van Hijum, S. A. F. T., de Vos, P., Kleerebezem, M. & Bron, P. A., 13 mei 2013, In: Plant Biotechnology Journal. 8, 8, blz. 895-904

Onderzoeksoutput: Article › Academic › peer review

Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness

Crul, T., Toth, N., Piotto, S., Literati-Nagy, P., Tory, K., Haldimann, P., Kalmar, B., Greensmith, L., Torok, Z., Balogh, G., Gombos, I., Campana, F., Concilio, S., Gallyas, F., Nagy, G., Berente, Z., Gungor, B., Peter, M., Glatz, A., Hunya, A., & 20 anderenLiterati-Nagy, Z., Vigh, L., Hoogstra-Berends, F., Heeres, A., Kuipers, I., Loen, L., Seerden, J-P., Zhang, D., Meijering, R. A. M., Henning, R. H., Brundel, B. J. J. M., Kampinga, H. H., Koranyi, L., Szilvassy, Z., Mandl, J., Sumegi, B., Febbraio, M. A., Horvath, I., Hooper, P. L. & Vigh, L., 2013, In: Current Pharmaceutical Design. 19, 3, blz. 309-346

Onderzoeksoutput: Article › Academic › peer review

Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Fleuren, W. WM., Toonen, E. JM., Verhoeven, S., Frijters, R., Hulsen, T., Rullmann, T., van Schaik, R., de Vlieg, J. & Alkema, W., 4 feb. 2013, In: BioData Mining. 6, 1, blz. 2 1 blz.

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Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren, W. W. M., Linssen, M. M. L., Toonen, E. J. M., van der Zon, G. C. M., Guigas, B., de Vlieg, J., Dokter, W. H. A., Ouwens, D. M. & Alkema, W., 19 mrt. 2013, In: Archives of Physiology and Biochemistry. 119, 2, blz. 52-64

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2012

Enzymatic degradation of granular potato starch by Microbacterium aurum strain B8.A

Sarian, F. D., van der Kaaij, R. M., Kralj, S., Wijbenga, D-J., Binnema, D. J., van der Maarel, M. J. E. C. & Dijkhuizen, L., jan. 2012, In: Applied Microbiology and Biotechnology. 93, 2, blz. 645-654

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Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation

Hoogstra-Berends, F., Meijering, R. A. M., Zhang, D., Heeres, A., Loen, L., Seerden, J-P., Kuipers, I., Kampinga, H. H., Henning, R. H. & Brundel, B. J. J. M., 1 apr. 2012, In: Trends in Cardiovascular Medicine. 22, 3, blz. 62-68

Onderzoeksoutput: Article › Academic › peer review

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Smeets, R. L., Fleuren, W. W. M., He, X., Vink, P. M., Wijnands, F., Gorecka, M., Klop, H., Bauerschmidt, S., Garritsen, A., Koenen, H. J. P. M., Joosten, I., Boots, A. M. H. & Alkema, W., 14 mrt. 2012, In: Molecular Immunology. 13, 12 blz.

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Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index

van Lierop, M-J. C., Alkema, W., Laskewitz, A. J., Dijkema, R., van der Maaden, H. M., Smit, M. J., Plate, R., Conti, P. G. M., Jans, C. G. J. M., Timmers, C. M., van Boeckel, C. A. A., Lusher, S. J., McGuire, R., van Schaik, R. C., de Vlieg, J., Smeets, R. L., Hofstra, C. L., Boots, A. M. H., van Duin, M., Ingelse, B. A., & 5 anderenSchoonen, W. G. E. J., Grefhorst, A., van Dijk, T. H., Kuipers, F. & Dokter, W. H. A., 12 nov. 2012, In: PLoS ONE. 7, 11

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Recent developments in basophil research: do basophils initiate and perpetuate type 2 T-helper cell responses?

van Beek, A. A., Knol, E. F., de Vos, P., Smelt, M. J., Savelkoul, H. F. J. & van Neerven, R. J. J., 30 aug. 2012, In: International Archives of Allergy and Immunology. 160, 1, blz. 7-17 11 blz.

Onderzoeksoutput: Article › Academic › peer review

2011

CoPub update: CoPub 5.0 a text mining system to answer biological questions

Fleuren, W. W. M., Verhoeven, S., Frijters, R., Heupers, B., Polman, J., van Schaik, R., de Vlieg, J. & Alkema, W., 27 mei 2011, In: Nucleic Acids Research. 39, SUPPL. 2, blz. 450-454 5 blz., Web-Server-Issue.

Onderzoeksoutput: Article › Academic › peer review

Open Access

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells

Linssen, M. M. L., van Raalte, D. H., Toonen, E. J. M., Alkema, W., van der Zon, G. C., Dokter, W. H., Diamant, M., Guigas, B. & Ouwens, D. M., 1 nov. 2011, In: Cellular Signalling. 23, 11, blz. 1708-1715

Onderzoeksoutput: Article › Academic › peer review

Prednisolone-induced changes in gene-expression profiles in healthy volunteers

Toonen, E. J. M., Fleuren, W. W. M., Nässander, U., van Lierop, M-J. C., Bauerschmidt, S., Dokter, W. H. A. & Alkema, W., 25 jul. 2011, In: Pharmacogenomics. 12, 7, blz. 985-998

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ss-TEA: entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs

umc, R., Fleuren, W. W. M., Verhoeven, S., van den Beld, S., Alkema, W., de Vlieg, J. & Klomp, J. P. G., 10 aug. 2011, In: Briefings in Bioinformatics. 12, blz. 332 1 blz.

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Structural surface changes and inflammatory responses against alginate-based microcapsules after exposure to human peritoneal fluid

de Haan, B. J., Rossi, A., Faas, M. M., Smelt, M. J., Sonvico, F., Colombo, P. & de Vos, P., 1 sep. 2011, In: Journal of Biomedical Materials Research Part A. 98, 3, blz. 394-403

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2010

Literature mining for the discovery of hidden connections between drugs, genes and diseases

Frijters, R., van Vugt, M., Smeets, R., van Schaik, R., de Vlieg, J. & Alkema, W., 23 sep. 2010, In: PLoS Computational Biology. 6, 9, 9.

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Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

Frijters, R., Fleuren, W., Toonen, E. J. M., Tuckermann, J. P., Reichardt, H. M., van der Maaden, H., van Elsas, A., van Lierop, M-J., Dokter, W., de Vlieg, J. & Alkema, W., 5 jun. 2010, In: BMC Genomics. 11, 1

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2009

PhyloPat: an updated version of the phylogenetic pattern database contains gene neighborhood

Hulsen, T., Groenen, P. M. A., de Vlieg, J. & Alkema, W., 1 jan. 2009, In: Nucleic Acids Research. 37, SUPPL. 1, blz. 731-737 7 blz., Database-Issue.

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Open Access

2008

BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

Hulsen, T., de Vlieg, J. & Alkema, W., 16 okt. 2008, In: BMC Genomics. 9

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Open Access

Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics

Jager, S. A. W., Shapovalova, I. V., Jekel, P. A., Alkema, W. B. L., Svedas, V. K. & Janssen, D. B., 1 jan. 2008, In: Journal of Biotechnology. 133, 1, blz. 18-26

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Synthesis, structure, and reactivity of rare-earth metallocene η3-propargyl/allenyl complexes

Norambuena, V. F. Q., Heeres, A., Heeres, H. J., Meetsma, A., Teuben, J. H. & Hessen, B., 7 okt. 2008, In: Organometallics. 27, 21, blz. 5672-5683

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Biobased Ingredients and Materials

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