Abstract
The copper(II) catalyzed enantioselective 1,4-addition reactions of diethylzinc to cyclic enones in the presence of novel phosphorus amidite ligands, easily prepared from α,α,α',α'-tetraphenyl-2,2'-dimethyl-1,3- dioxolane-4,5-dimethanol (TADDOL) derivatives, resulted in e.e.s up to 71% for cyclohexenone and up to 62% for cyclopentenone. A remarkable enhancement of enantioselectivity was observed upon the addition of powdered molecular sieves to the reaction mixture.
Original language | English |
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Pages (from-to) | 2409-2413 |
Journal | Tetrahedron: asymmetry |
Volume | 9 |
Issue number | 14 |
DOIs | |
Publication status | Published - 17 Jul 1998 |
Keywords
- copper