Tolerance of organ transplant recipients to physical activity during a high-altitude expedition: climbing Mount Kilimanjaro

Edwin van Adrichem, Marion J Siebelink, Bart L Rottier, Janneke M. Dilling, Greetje Kuiken, Cees van der Schans, Erik A.M. Verschuuren

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: It is generally unknown to what extent organ transplant recipients can be physically challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous physical activity and high-altitude of organ transplant recipients after various types of transplantation was compared to non-transplanted controls.

METHODS: Twelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-, 4 liver-, 1 allogeneic stem cell- and 1 small bowel-transplantation). Controls comprised the members of the medical team and accompanying family members (n = 14). During the climb, cardiopulmonary parameters and symptoms of acute mountain sickness were recorded twice daily. Capillary blood analyses were performed three times during the climb and once following return.

RESULTS: Eleven of the transplant participants and all controls began the final ascent from 4700 meters and reached over 5000 meters. Eight transplant participants (73%) and thirteen controls (93%) reached the summit (5895m). Cardiopulmonary parameters and altitude sickness scores demonstrated no differences between transplant participants and controls. Signs of hyperventilation were more pronounced in transplant participants and adaptation to high-altitude was less effective, which was related to a decreased renal function. This resulted in reduced metabolic compensation.

CONCLUSION: Overall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition in carefully selected organ transplant recipients is comparable to non-transplanted controls.

Original languageEnglish
Number of pages13
JournalPLOS one
Volume10
Issue number11
DOIs
Publication statusPublished - 1 Nov 2015

Keywords

  • acclimatization
  • adults
  • altitude
  • altitude sickness
  • blood pressure
  • exercise test
  • expeditions
  • heart rate
  • humans
  • middle aged
  • mountaineering
  • muscle strength
  • organ transplantation
  • prospective studies
  • tanzania
  • transplant recipients

Cite this

van Adrichem, Edwin ; Siebelink, Marion J ; Rottier, Bart L ; Dilling, Janneke M. ; Kuiken, Greetje ; van der Schans, Cees ; Verschuuren, Erik A.M. / Tolerance of organ transplant recipients to physical activity during a high-altitude expedition : climbing Mount Kilimanjaro. In: PLOS one. 2015 ; Vol. 10, No. 11.
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abstract = "BACKGROUND: It is generally unknown to what extent organ transplant recipients can be physically challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous physical activity and high-altitude of organ transplant recipients after various types of transplantation was compared to non-transplanted controls.METHODS: Twelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-, 4 liver-, 1 allogeneic stem cell- and 1 small bowel-transplantation). Controls comprised the members of the medical team and accompanying family members (n = 14). During the climb, cardiopulmonary parameters and symptoms of acute mountain sickness were recorded twice daily. Capillary blood analyses were performed three times during the climb and once following return.RESULTS: Eleven of the transplant participants and all controls began the final ascent from 4700 meters and reached over 5000 meters. Eight transplant participants (73{\%}) and thirteen controls (93{\%}) reached the summit (5895m). Cardiopulmonary parameters and altitude sickness scores demonstrated no differences between transplant participants and controls. Signs of hyperventilation were more pronounced in transplant participants and adaptation to high-altitude was less effective, which was related to a decreased renal function. This resulted in reduced metabolic compensation.CONCLUSION: Overall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition in carefully selected organ transplant recipients is comparable to non-transplanted controls.",
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Tolerance of organ transplant recipients to physical activity during a high-altitude expedition : climbing Mount Kilimanjaro. / van Adrichem, Edwin; Siebelink, Marion J; Rottier, Bart L; Dilling, Janneke M.; Kuiken, Greetje; van der Schans, Cees; Verschuuren, Erik A.M.

In: PLOS one, Vol. 10, No. 11, 01.11.2015.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Tolerance of organ transplant recipients to physical activity during a high-altitude expedition

T2 - climbing Mount Kilimanjaro

AU - van Adrichem, Edwin

AU - Siebelink, Marion J

AU - Rottier, Bart L

AU - Dilling, Janneke M.

AU - Kuiken, Greetje

AU - van der Schans, Cees

AU - Verschuuren, Erik A.M.

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N2 - BACKGROUND: It is generally unknown to what extent organ transplant recipients can be physically challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous physical activity and high-altitude of organ transplant recipients after various types of transplantation was compared to non-transplanted controls.METHODS: Twelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-, 4 liver-, 1 allogeneic stem cell- and 1 small bowel-transplantation). Controls comprised the members of the medical team and accompanying family members (n = 14). During the climb, cardiopulmonary parameters and symptoms of acute mountain sickness were recorded twice daily. Capillary blood analyses were performed three times during the climb and once following return.RESULTS: Eleven of the transplant participants and all controls began the final ascent from 4700 meters and reached over 5000 meters. Eight transplant participants (73%) and thirteen controls (93%) reached the summit (5895m). Cardiopulmonary parameters and altitude sickness scores demonstrated no differences between transplant participants and controls. Signs of hyperventilation were more pronounced in transplant participants and adaptation to high-altitude was less effective, which was related to a decreased renal function. This resulted in reduced metabolic compensation.CONCLUSION: Overall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition in carefully selected organ transplant recipients is comparable to non-transplanted controls.

AB - BACKGROUND: It is generally unknown to what extent organ transplant recipients can be physically challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous physical activity and high-altitude of organ transplant recipients after various types of transplantation was compared to non-transplanted controls.METHODS: Twelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-, 4 liver-, 1 allogeneic stem cell- and 1 small bowel-transplantation). Controls comprised the members of the medical team and accompanying family members (n = 14). During the climb, cardiopulmonary parameters and symptoms of acute mountain sickness were recorded twice daily. Capillary blood analyses were performed three times during the climb and once following return.RESULTS: Eleven of the transplant participants and all controls began the final ascent from 4700 meters and reached over 5000 meters. Eight transplant participants (73%) and thirteen controls (93%) reached the summit (5895m). Cardiopulmonary parameters and altitude sickness scores demonstrated no differences between transplant participants and controls. Signs of hyperventilation were more pronounced in transplant participants and adaptation to high-altitude was less effective, which was related to a decreased renal function. This resulted in reduced metabolic compensation.CONCLUSION: Overall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition in carefully selected organ transplant recipients is comparable to non-transplanted controls.

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KW - blood pressure

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KW - heart rate

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KW - mountaineering

KW - muscle strength

KW - organ transplantation

KW - prospective studies

KW - tanzania

KW - transplant recipients

KW - acclimatisatie

KW - volwassene

KW - hoogte

KW - hoogteziekte

KW - bloeddruk

KW - case control study

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KW - vrouwelijk

KW - hartslag

KW - mensen

KW - middelbaar

KW - alpinisme

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KW - orgaantransplantatie

KW - toekomstige studies

KW - tanzania

KW - transplantatiepatiënten

KW - tijdschriftartikel

KW - esearch support, non-U.S. Gov't

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