The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

Hans Drenth (First author), Johannes Hobbelen, Sytse U Zuidema, Ivan Bautmans

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Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.
Translated title of the contributionDe rol van ontsteking en versuikerde eiwitten bij paratonie bij mensen met dementie
Original languageEnglish
JournalExperimental Gerontology
Issue numberDecember
Publication statusPublished - 22 Oct 2020


  • gerontology
  • dementia
  • paratonia
  • oxidative stress
  • advanced glycation end products

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