The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

Hans Drenth; Johannes Hobbelen; Sytse U Zuidema; Ivan Bautmans

doi:10.1016/j.exger.2020.111125

The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

Hans Drenth (First author), Johannes Hobbelen, Sytse U Zuidema, Ivan Bautmans

University of Groningen, University Medical Center Groningen, Faculty of Medical Sciences, Department of General Practice, Geriatrics
Vrije Universiteit, Frailty in Aging Research Group and Gerontology Department

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.

Translated title of the contribution	De rol van ontsteking en versuikerde eiwitten bij paratonie bij mensen met dementie
Original language	English
Journal	Experimental Gerontology
Volume	142
Issue number	December
DOIs	https://doi.org/10.1016/j.exger.2020.111125
Publication status	Published - 22 Oct 2020

Keywords

gerontology
dementia
paratonia
oxidative stress
advanced glycation end products

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10.1016/j.exger.2020.111125Licence: CC BY

Move in Age: International Joint Research Group 'Move in Age'
Hobbelen, H. (PI), Drenth, H. (PI), Zuidema, S. U. (PI) & Bautmans, I. (PI)
1/01/18 → …
Project: Research

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abstract = "Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.",

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AU - Bautmans, Ivan

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N2 - Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.

AB - Impaired motor function is a prominent characteristic of aging. Inflammatory processes and oxidative stress from advanced glycation end-products are related to impaired motor function and could plausibly be a contributing factor to the pathogenesis of paratonia, a specific motor disorder in people with dementia. Severe paratonia results in a substantial increase of a caretaker's burden and a decrease in the quality of life. The pathogenesis of paratonia is not well understood, and no effective interventions are available to combat it. Intensive glycaemic control, reducing oxidative stress, possibly combined with a low AGE diet and AGE targeting medication may be the key method for preventing advanced glycation end-product accumulation and reducing the inflammatory burden as well as possibly postponing or preventing paratonia.

KW - paratonie

KW - dementie

KW - immunologie

KW - gerontology

KW - dementia

KW - paratonia

KW - oxidative stress

KW - advanced glycation end products

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DO - 10.1016/j.exger.2020.111125

M3 - Article

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VL - 142

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - December

ER -

The role of inflammaging and advanced glycation end products on paratonia in patients with dementia

Abstract

Keywords

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Move in Age: International Joint Research Group 'Move in Age'

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