The added value of ultrasound muscle measurements in patients with COPD: an exploratory study

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND AND AIMS: Malnutrition and sarcopenia are common nutrition (-related) disorders in patients with COPD and are associated with negative health outcomes and mortality. This study aims to correlate ultrasound measured rectus femoris size with fat-free mass and muscle function in patients with COPD.

METHODS: Patients with COPD, at the start of a pulmonary rehabilitation program, were asked to participate in this study. Rectus femoris (RF) size (thickness in cm, cross-sectional area [CSA] in cm2) was determined by ultrasound. Fat-free mass index (FFMI in kg/m2) was estimated with bioelectrical impedance analyses, using a disease-specific equation. Handgrip strength (HGS) was measured in kilograms and the five times sit to stand test (in seconds, higher scores indicating decreased strength) was performed to assess leg muscle power. The Incremental Shuttle Walk Test (ISWT, in m) was used to assess maximal exercise capacity.

RESULTS: In total, 44 patients with COPD (mean age 59.8 ± 8.6 years, 43% male, median FEV1%pred 37 [IQR = 23-52]) were included. Greater RF-CSA and thickness were associated with higher FFMI (r = 0.57, p < 0.001; r = 0.53, p = 0.003, respectively) and HGS (CSA r = 0.58, p < 0.001, thickness r = 0.48, p = 0.009). No significant correlations between RF-thickness, CSA, and leg muscle power were found (r = -0.33, p = 0.091; r = -0.35, p = 0.073, respectively). Furthermore, no correlation between RF size and maximal exercise capacity was observed (thickness r = 0.21, p = 0.297, CSA r = 0.22, p = 0.274).

CONCLUSIONS: This exploratory study shows that in patients with COPD, rectus femoris size is moderately correlated with FFMI and HGS. Future studies should focus on the role of ultrasound in evaluating nutritional status.

Original languageEnglish
Pages (from-to)152-158
JournalClinical Nutrition ESPEN
Volume30
Issue numberapril
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • malnutrition
  • sarcopenia

Cite this

@article{4865a5195870411abc223e53c3b8d6f7,
title = "The added value of ultrasound muscle measurements in patients with COPD: an exploratory study",
abstract = "BACKGROUND AND AIMS: Malnutrition and sarcopenia are common nutrition (-related) disorders in patients with COPD and are associated with negative health outcomes and mortality. This study aims to correlate ultrasound measured rectus femoris size with fat-free mass and muscle function in patients with COPD.METHODS: Patients with COPD, at the start of a pulmonary rehabilitation program, were asked to participate in this study. Rectus femoris (RF) size (thickness in cm, cross-sectional area [CSA] in cm2) was determined by ultrasound. Fat-free mass index (FFMI in kg/m2) was estimated with bioelectrical impedance analyses, using a disease-specific equation. Handgrip strength (HGS) was measured in kilograms and the five times sit to stand test (in seconds, higher scores indicating decreased strength) was performed to assess leg muscle power. The Incremental Shuttle Walk Test (ISWT, in m) was used to assess maximal exercise capacity.RESULTS: In total, 44 patients with COPD (mean age 59.8 ± 8.6 years, 43{\%} male, median FEV1{\%}pred 37 [IQR = 23-52]) were included. Greater RF-CSA and thickness were associated with higher FFMI (r = 0.57, p < 0.001; r = 0.53, p = 0.003, respectively) and HGS (CSA r = 0.58, p < 0.001, thickness r = 0.48, p = 0.009). No significant correlations between RF-thickness, CSA, and leg muscle power were found (r = -0.33, p = 0.091; r = -0.35, p = 0.073, respectively). Furthermore, no correlation between RF size and maximal exercise capacity was observed (thickness r = 0.21, p = 0.297, CSA r = 0.22, p = 0.274).CONCLUSIONS: This exploratory study shows that in patients with COPD, rectus femoris size is moderately correlated with FFMI and HGS. Future studies should focus on the role of ultrasound in evaluating nutritional status.",
keywords = "malnutrition, sarcopenia, ondervoeding, sarcopenie",
author = "Willemke Nijholt and {ter Beek}, Lies and {van der Vaart}, Hester and Wempe, {Johan B.} and {van der Schans}, {Cees P.} and Harri{\"e}t Jager-Wittenaar and Johannes Hobbelen",
note = "Copyright {\circledC} 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.clnesp.2019.01.001",
language = "English",
volume = "30",
pages = "152--158",
journal = "Clinical Nutrition ESPEN",
issn = "2405-4577",
publisher = "Elsevier",
number = "april",

}

The added value of ultrasound muscle measurements in patients with COPD : an exploratory study. / Nijholt, Willemke; ter Beek, Lies ; van der Vaart, Hester; Wempe, Johan B.; van der Schans, Cees P.; Jager-Wittenaar, Harriët; Hobbelen, Johannes.

In: Clinical Nutrition ESPEN, Vol. 30, No. april, 01.04.2019, p. 152-158.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The added value of ultrasound muscle measurements in patients with COPD

T2 - an exploratory study

AU - Nijholt, Willemke

AU - ter Beek, Lies

AU - van der Vaart, Hester

AU - Wempe, Johan B.

AU - van der Schans, Cees P.

AU - Jager-Wittenaar, Harriët

AU - Hobbelen, Johannes

N1 - Copyright © 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - BACKGROUND AND AIMS: Malnutrition and sarcopenia are common nutrition (-related) disorders in patients with COPD and are associated with negative health outcomes and mortality. This study aims to correlate ultrasound measured rectus femoris size with fat-free mass and muscle function in patients with COPD.METHODS: Patients with COPD, at the start of a pulmonary rehabilitation program, were asked to participate in this study. Rectus femoris (RF) size (thickness in cm, cross-sectional area [CSA] in cm2) was determined by ultrasound. Fat-free mass index (FFMI in kg/m2) was estimated with bioelectrical impedance analyses, using a disease-specific equation. Handgrip strength (HGS) was measured in kilograms and the five times sit to stand test (in seconds, higher scores indicating decreased strength) was performed to assess leg muscle power. The Incremental Shuttle Walk Test (ISWT, in m) was used to assess maximal exercise capacity.RESULTS: In total, 44 patients with COPD (mean age 59.8 ± 8.6 years, 43% male, median FEV1%pred 37 [IQR = 23-52]) were included. Greater RF-CSA and thickness were associated with higher FFMI (r = 0.57, p < 0.001; r = 0.53, p = 0.003, respectively) and HGS (CSA r = 0.58, p < 0.001, thickness r = 0.48, p = 0.009). No significant correlations between RF-thickness, CSA, and leg muscle power were found (r = -0.33, p = 0.091; r = -0.35, p = 0.073, respectively). Furthermore, no correlation between RF size and maximal exercise capacity was observed (thickness r = 0.21, p = 0.297, CSA r = 0.22, p = 0.274).CONCLUSIONS: This exploratory study shows that in patients with COPD, rectus femoris size is moderately correlated with FFMI and HGS. Future studies should focus on the role of ultrasound in evaluating nutritional status.

AB - BACKGROUND AND AIMS: Malnutrition and sarcopenia are common nutrition (-related) disorders in patients with COPD and are associated with negative health outcomes and mortality. This study aims to correlate ultrasound measured rectus femoris size with fat-free mass and muscle function in patients with COPD.METHODS: Patients with COPD, at the start of a pulmonary rehabilitation program, were asked to participate in this study. Rectus femoris (RF) size (thickness in cm, cross-sectional area [CSA] in cm2) was determined by ultrasound. Fat-free mass index (FFMI in kg/m2) was estimated with bioelectrical impedance analyses, using a disease-specific equation. Handgrip strength (HGS) was measured in kilograms and the five times sit to stand test (in seconds, higher scores indicating decreased strength) was performed to assess leg muscle power. The Incremental Shuttle Walk Test (ISWT, in m) was used to assess maximal exercise capacity.RESULTS: In total, 44 patients with COPD (mean age 59.8 ± 8.6 years, 43% male, median FEV1%pred 37 [IQR = 23-52]) were included. Greater RF-CSA and thickness were associated with higher FFMI (r = 0.57, p < 0.001; r = 0.53, p = 0.003, respectively) and HGS (CSA r = 0.58, p < 0.001, thickness r = 0.48, p = 0.009). No significant correlations between RF-thickness, CSA, and leg muscle power were found (r = -0.33, p = 0.091; r = -0.35, p = 0.073, respectively). Furthermore, no correlation between RF size and maximal exercise capacity was observed (thickness r = 0.21, p = 0.297, CSA r = 0.22, p = 0.274).CONCLUSIONS: This exploratory study shows that in patients with COPD, rectus femoris size is moderately correlated with FFMI and HGS. Future studies should focus on the role of ultrasound in evaluating nutritional status.

KW - malnutrition

KW - sarcopenia

KW - ondervoeding

KW - sarcopenie

UR - http://www.mendeley.com/research/added-value-ultrasound-muscle-measurements-patients-copd-exploratory-study-1

U2 - 10.1016/j.clnesp.2019.01.001

DO - 10.1016/j.clnesp.2019.01.001

M3 - Article

VL - 30

SP - 152

EP - 158

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

SN - 2405-4577

IS - april

ER -