SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

Christa Dijkhuizen; Patrick  Korthuis; Juliana F. Vilachã; Maaike Smelt; Anthonie van der Wekken; Anke van den Berg; Lyndsay Drayer

SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

Christa Dijkhuizen (First author), Patrick Korthuis, Juliana F. Vilachã, Maaike Smelt, Anthonie van der Wekken, Anke van den Berg, Lyndsay Drayer

Biomolecules & Health

University of Groningen, Faculty of Science and Engineering, Molecular Dynamics — Groningen Biomolecular Sciences and Biotechnology
University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine
University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology

Research output: Contribution to conference › Abstract › Academic

36 Downloads (Pure)

Original language	English
Number of pages	2
Publication status	Published - 2023
Event	European Society for Medial Oncology 2023 Conference - Madrid, Spain Duration: 20 Oct 2023 → 24 Oct 2023

Conference

Conference	European Society for Medial Oncology 2023 Conference
Abbreviated title	ESMO2023
Country/Territory	Spain
City	Madrid
Period	20/10/23 → 24/10/23

Keywords

ROS1
Ba/F3 cells
molecular dynamics simulation
ROS1 inhibitors

Research Focus Areas Hanze University of Applied Sciences * (mandatory by Hanze)

Healthy Ageing

Research Focus Areas Research Centre or Centre of Expertise * (mandatory by Hanze)

Medical Diagnostics & Point of Care Testing
Healthcare & Biotechnology

Publinova themes

Health

Access to Document

Abstract ESMO Madrid 2023 C.O.DijkhuizenSubmitted manuscript, 234 KB

Cite this

@conference{3f4f52e9932a41238ba7a81afa238dac,

title = "SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume",

keywords = "ROS1, Ba/F3 cells, molecular dynamics simulation, ROS1 inhibitors, ROS1, BA F3-cellen, moleculaire dynamica simulatie, ROS1-remmers",

author = "Christa Dijkhuizen and Patrick Korthuis and Vilach{\~a}, \{Juliana F.\} and Maaike Smelt and \{van der Wekken\}, Anthonie and \{van den Berg\}, Anke and Lyndsay Drayer",

year = "2023",

language = "English",

note = "European Society for Medial Oncology 2023 Conference, ESMO2023 ; Conference date: 20-10-2023 Through 24-10-2023",

}

SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume. / Dijkhuizen, Christa (First author); Korthuis, Patrick ; Vilachã, Juliana F. et al.
2023. Abstract from European Society for Medial Oncology 2023 Conference, Madrid, Spain.

Research output: Contribution to conference › Abstract › Academic

TY - CONF

T1 - SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

AU - Dijkhuizen, Christa

AU - Korthuis, Patrick

AU - Vilachã, Juliana F.

AU - Smelt, Maaike

AU - van der Wekken, Anthonie

AU - van den Berg, Anke

AU - Drayer, Lyndsay

PY - 2023

Y1 - 2023

KW - ROS1

KW - Ba/F3 cells

KW - molecular dynamics simulation

KW - ROS1 inhibitors

KW - ROS1

KW - BA F3-cellen

KW - moleculaire dynamica simulatie

KW - ROS1-remmers

M3 - Abstract

T2 - European Society for Medial Oncology 2023 Conference

Y2 - 20 October 2023 through 24 October 2023

ER -