Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

André Heeres; Hu Xu; Denise MS van Marion; Femke Hoogstra-Berends; Deli Zhang; Jean-Paul Seerden; Lizette Loen; Herman Steen; Robert H Henning; Bianca J J M Brundel

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

André Heeres
, Hu Xu (First author)
, Denise MS van Marion (First author)
, Femke Hoogstra-Berends
, Deli Zhang
, Jean-Paul Seerden
, Lizette Loen
, Herman Steen
, Robert H Henning
, Bianca J J M Brundel

Syncom B.V.
Chaperone Pharma BV
University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology
Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA.

Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

Original language	English
Pages (from-to)	345—364
Journal	Drug Design, Development and Therapy
Volume	13
Publication status	Published - 18 Jan 2019

Keywords

atrial fibrillation
heat shock protein
drosophila
proteostasis
geranylgeranylacetone

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f_dddt-176924-screening-of-novel-hsp-inducing-compounds-to-conserve-cardio-011719_47595Final published version, 6.39 MBLicence: CC BY-NC

4 Article

Substituted anilides from chitin-based 3-acetamido-furfural
van der Loo, C., Kaniraj, J. P., Wang, T., Pouwer, K., Broekman, O., Borst, M., Heeres, A., Deuss, P. & Minnaard, A., 5 Oct 2023, In: Organic and Biomolecular Chemistry. 21, 41, p. 8372-8378 7 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
Catalytic Conversion of Free Fatty Acids to Bio-Based Aromatics: A Model Investigation Using Oleic Acid and an H-ZSM-5/Al2O3 Catalyst
He, S., Klein, F., Kramer, T. S., Chandel, A., Tegudeer, Z., Heeres, A. & Heeres, H. J., 10 Jan 2021, In: ACS Sustainable Chemistry and Engineering. 9, 3, p. 1128-1141 14 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
Catalytic conversion of glycerol and co-feeds (fatty acids, alcohols, and alkanes) to bio-based aromatics: remarkable and unprecedented synergetic effects on catalyst performance
He, S., Kramer, T. S., Sukmayanda Santosa, D., Heeres, A. & Heeres, H. J., 18 Dec 2021, In: Green Chemistry. 24, 2, p. 941-949 9 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access

1 Oral presentation

Sustainable building blocks at the Hanze
Heeres, A. (Speaker)
6 Jun 2023
Activity: Talk or presentation › Oral presentation

Cite this

@article{ef625647f17546f9936c7670b3195a54,

title = "Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation",

abstract = "Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA. Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.",

keywords = "atrial fibrillation, heat shock protein, drosophila, proteostasis, geranylgeranylacetone, hartaandoeningen",

author = "Andr{\'e} Heeres and Hu Xu and \{van Marion\}, \{Denise MS\} and Femke Hoogstra-Berends and Deli Zhang and Jean-Paul Seerden and Lizette Loen and Herman Steen and Henning, \{Robert H\} and Brundel, \{Bianca J J M\}",

year = "2019",

month = jan,

day = "18",

language = "English",

volume = "13",

pages = " 345—364 ",

journal = "Drug Design, Development and Therapy",

issn = "1177-8881",

publisher = "Dove Press Limited",

}

TY - JOUR

T1 - Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

AU - Heeres, André

AU - Xu , Hu

AU - van Marion, Denise MS

AU - Hoogstra-Berends, Femke

AU - Zhang, Deli

AU - Seerden, Jean-Paul

AU - Loen, Lizette

AU - Steen, Herman

AU - Henning, Robert H

AU - Brundel, Bianca J J M

PY - 2019/1/18

Y1 - 2019/1/18

N2 - Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA. Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

AB - Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA. Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

KW - atrial fibrillation

KW - heat shock protein

KW - drosophila

KW - proteostasis

KW - geranylgeranylacetone

KW - hartaandoeningen

M3 - Article

SN - 1177-8881

VL - 13

SP - 345—364

JO - Drug Design, Development and Therapy

JF - Drug Design, Development and Therapy

ER -

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Abstract

Keywords

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Research output

Substituted anilides from chitin-based 3-acetamido-furfural

Catalytic Conversion of Free Fatty Acids to Bio-Based Aromatics: A Model Investigation Using Oleic Acid and an H-ZSM-5/Al2O3 Catalyst

Catalytic conversion of glycerol and co-feeds (fatty acids, alcohols, and alkanes) to bio-based aromatics: remarkable and unprecedented synergetic effects on catalyst performance

Activities

Sustainable building blocks at the Hanze

Cite this