Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

André Heeres; Hu Xu; Denise MS van Marion; Femke Hoogstra-Berends; Deli Zhang; Jean-Paul Seerden; Lizette Loen; Herman Steen; Robert H Henning; Bianca J J M Brundel

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

André Heeres, Hu Xu (First author), Denise MS van Marion (First author), Femke Hoogstra-Berends, Deli Zhang, Jean-Paul Seerden, Lizette Loen, Herman Steen, Robert H Henning, Bianca J J M Brundel

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Abstract

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA.

Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

Original language	English
Pages (from-to)	345—364
Journal	Drug Design, Development and Therapy
Volume	13
Publication status	Published - 18 Jan 2019

Keywords

atrial fibrillation
heat shock protein
drosophila
proteostasis
geranylgeranylacetone

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GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2
Heeres, A., van der Hoek, S., Antunes, I. F., Attia, K. A., Jacquet, O., Bulthuis, M., Zijlma, R., Boersma, H. H., van Goor, H., Visser, T. J., Heerspink, H. J. L., Elsinga, P. H. & Stevens, J., 8 Nov 2021, In: Journal of Medicinal Chemistry.
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Heeres, André ; Xu , Hu ; van Marion, Denise MS ; Hoogstra-Berends, Femke ; Zhang, Deli ; Seerden, Jean-Paul ; Loen, Lizette ; Steen, Herman ; Henning, Robert H ; Brundel, Bianca J J M. / Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation. In: Drug Design, Development and Therapy. 2019 ; Vol. 13. pp. 345—364 .

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title = "Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation",

abstract = "Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA.Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.",

keywords = "atrial fibrillation, heat shock protein, drosophila, proteostasis, geranylgeranylacetone, hartaandoeningen",

author = "Andr{\'e} Heeres and Hu Xu and {van Marion}, {Denise MS} and Femke Hoogstra-Berends and Deli Zhang and Jean-Paul Seerden and Lizette Loen and Herman Steen and Henning, {Robert H} and Brundel, {Bianca J J M}",

year = "2019",

month = jan,

day = "18",

language = "English",

volume = "13",

pages = " 345—364 ",

journal = "Drug Design, Development and Therapy",

issn = "1177-8881",

publisher = "Dove Press Limited",

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Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation. / Heeres, André; Xu , Hu (First author); van Marion, Denise MS (First author); Hoogstra-Berends, Femke; Zhang, Deli; Seerden, Jean-Paul; Loen, Lizette; Steen, Herman; Henning, Robert H; Brundel, Bianca J J M.

In: Drug Design, Development and Therapy, Vol. 13, 18.01.2019, p. 345—364 .

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

AU - Heeres, André

AU - Xu , Hu

AU - van Marion, Denise MS

AU - Hoogstra-Berends, Femke

AU - Zhang, Deli

AU - Seerden, Jean-Paul

AU - Loen, Lizette

AU - Steen, Herman

AU - Henning, Robert H

AU - Brundel, Bianca J J M

PY - 2019/1/18

Y1 - 2019/1/18

N2 - Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA.Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

AB - Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA.Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

KW - atrial fibrillation

KW - heat shock protein

KW - drosophila

KW - proteostasis

KW - geranylgeranylacetone

KW - hartaandoeningen

M3 - Article

VL - 13

SP - 345—364

JO - Drug Design, Development and Therapy

JF - Drug Design, Development and Therapy

SN - 1177-8881

ER -

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Abstract

Keywords

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Research output

GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Cite this