Responsive cyclohexane-based low-molecular-weight hydrogelators with modular architecture

Kjeld J C van Bommel, Cornelia van der Pol, Inouk Muizebelt, Arianna Friggeri, André Heeres, Auke Meetsma, Ben L Feringa, Jan van Esch

Research output: Contribution to journalArticleAcademicpeer-review


pH-sensitive gels: By using a cyclohexane-based scaffold to which various amino acid based substituents can be connected, low-molecular-weight compounds were obtained that can gelate water at very low concentrations. Their modular design (see picture: AA = amino acid(s), X = hydrophilic substituent, dark purple = hydrophobic region, light purple = hydrophilic region), allows tuning of the thermally and pH-induced reversible gel-to-sol transition of their gels.
Original languageEnglish
Pages (from-to)1663-1667
JournalAngewandte Chemie (International ed. in English)
Issue number13
Publication statusPublished - 19 Mar 2004


  • crystallography, x-ray
  • cyclohexanes
  • hydrogels
  • hydrogen-ion concentration
  • models, molecular
  • molecular conformation
  • molecular weight


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