Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations

Martin Krššák, Lucas Lindeboom, Vera Schrauwen-Hinderling, Lidia S Szczepaniak, Wim Derave, Jesper Lundbom, Douglas Befroy, Fritz Schick, Jürgen Machann, Roland Kreis, Chris Boesch

Research output: Contribution to journalReview articlepeer-review


1 H-MR spectroscopy of skeletal muscle provides insight into metabolism that is not available noninvasively by other methods. The recommendations given in this article are intended to guide those who have basic experience in general MRS to the special application of 1 H-MRS in skeletal muscle. The highly organized structure of skeletal muscle leads to effects that change spectral features far beyond simple peak heights, depending on the type and orientation of the muscle. Specific recommendations are given for the acquisition of three particular metabolites (intramyocellular lipids, carnosine and acetylcarnitine) and for preconditioning of experiments and instructions to study volunteers.

Original languageEnglish
Article numbere4266
JournalNMR in Biomedicine
Issue number5
Publication statusPublished - 5 Feb 2020
Externally publishedYes


  • consensus
  • expert testimony
  • humans
  • metabolic networks and pathways
  • metabolome
  • muscle, skeletal/anatomy & histology
  • proton magnetic resonance spectroscopy


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