Physical activity is associated with positive patient and clinical outcomes following dysvascular major lower limb amputation

Leonie A. Krops; Harriët Jager-Wittenaar; Wim Krijnen; Martijn Dijkstra; B Paul J A Keller; Jacques Oskam; Bastiaan Vierhout; Jean-Paul de Vries; Laurens van Walraven; Jan HB Geertzen; Rienk Dekker; Aniek M Kolen

doi:10.1016/j.jvs.2025.10.040

Physical activity is associated with positive patient and clinical outcomes following dysvascular major lower limb amputation

Leonie A. Krops (First author)
, Harriët Jager-Wittenaar
, Wim Krijnen
, Martijn Dijkstra
, B Paul J A Keller
, Jacques Oskam
, Bastiaan Vierhout
, Jean-Paul de Vries
, Laurens van Walraven
, Jan HB Geertzen
, Rienk Dekker
, Aniek M Kolen

University of Groningen, University Medical Center Groningen, Department of Rehabilitation Medicine
Radboud University Medical Center, Department of Gastroenterology and Hepatology, Dietetics
Vrije Universiteit Brussel, Faculty of Physical Education and Physiotherapy, Department Physiotherapy and Human Anatomy, Research unit Experimental Anatomy
University of Groningen, University Medical Center Groningen, Department of Surgery, Division of Vascular Surgery
Martini Hospital, Department of Vascular Surgery
Isala Hospital, Department of Surgery, Division of Vascular Surgery
Treant Hospital, Department of Surgery
Medical Center Leeuwarden, Department of Vascular Surgery

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To determine the association between physical activity (PA; duration and intensity) and patient and clinical outcomes at various measurement occasions post dysvascular major lower limb amputation (LLA). Methods: In this multicenter longitudinal observational study, the PA levels of adults who underwent dysvascular major LLA (n = 81) were assessed using the adapted Short Questionnaire to Assess Health-enhancing Physical Activity questionnaire (total hours, hours of moderate/vigorous, and metabolic equivalent of task-hours/week), at

Original language	English
Pages (from-to)	866-878
Number of pages	13
Journal	Annals of Vascular Surgery
Volume	83
Issue number	3
Early online date	4 Nov 2025
DOIs	https://doi.org/10.1016/j.jvs.2025.10.040
Publication status	Published - Mar 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 03 Good Health and Well-being

Keywords

amputation
exercise
outcomes
peripheral arterial disease
physical activity

Research Focus Areas Hanze University of Applied Sciences * (mandatory by Hanze)

Healthy Ageing

Research Focus Areas Research Centre or Centre of Expertise * (mandatory by Hanze)

Frailty and adequate care

Publinova themes

Other
Health

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10.1016/j.jvs.2025.10.040Licence: CC BY

Cite this

Krops, L. A., Jager-Wittenaar, H., Krijnen, W., Dijkstra, M., Keller, B. P. J. A., Oskam, J., Vierhout, B., de Vries, J.-P., van Walraven, L., Geertzen, J. HB., Dekker, R., & Kolen, A. M. (2026). Physical activity is associated with positive patient and clinical outcomes following dysvascular major lower limb amputation. Annals of Vascular Surgery, 83(3), 866-878. https://doi.org/10.1016/j.jvs.2025.10.040

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title = "Physical activity is associated with positive patient and clinical outcomes following dysvascular major lower limb amputation",

abstract = "Objective: To determine the association between physical activity (PA; duration and intensity) and patient and clinical outcomes at various measurement occasions post dysvascular major lower limb amputation (LLA). Methods: In this multicenter longitudinal observational study, the PA levels of adults who underwent dysvascular major LLA (n = 81) were assessed using the adapted Short Questionnaire to Assess Health-enhancing Physical Activity questionnaire (total hours, hours of moderate/vigorous, and metabolic equivalent of task-hours/week), at ",

keywords = "amputation, exercise, outcomes, peripheral arterial disease, physical activity, amputatie, beweging, fysieke activiteit, perifeer arterieel vaatlijden, uitkomsten",

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year = "2026",

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doi = "10.1016/j.jvs.2025.10.040",

language = "English",

volume = "83",

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journal = "Annals of Vascular Surgery",

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Krops, LA, Jager-Wittenaar, H , Krijnen, W, Dijkstra, M, Keller, BPJA, Oskam, J, Vierhout, B, de Vries, J-P, van Walraven, L, Geertzen, JHB, Dekker, R & Kolen, AM 2026, 'Physical activity is associated with positive patient and clinical outcomes following dysvascular major lower limb amputation', Annals of Vascular Surgery, vol. 83, no. 3, pp. 866-878. https://doi.org/10.1016/j.jvs.2025.10.040

TY - JOUR

T1 - Physical activity is associated with positive patient and clinical outcomes following dysvascular major lower limb amputation

AU - Krops, Leonie A.

AU - Jager-Wittenaar, Harriët

AU - Krijnen, Wim

AU - Dijkstra, Martijn

AU - Keller, B Paul J A

AU - Oskam, Jacques

AU - Vierhout, Bastiaan

AU - de Vries, Jean-Paul

AU - van Walraven, Laurens

AU - Geertzen, Jan HB

AU - Dekker, Rienk

AU - Kolen, Aniek M

PY - 2026/3

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N2 - Objective: To determine the association between physical activity (PA; duration and intensity) and patient and clinical outcomes at various measurement occasions post dysvascular major lower limb amputation (LLA). Methods: In this multicenter longitudinal observational study, the PA levels of adults who underwent dysvascular major LLA (n = 81) were assessed using the adapted Short Questionnaire to Assess Health-enhancing Physical Activity questionnaire (total hours, hours of moderate/vigorous, and metabolic equivalent of task-hours/week), at

AB - Objective: To determine the association between physical activity (PA; duration and intensity) and patient and clinical outcomes at various measurement occasions post dysvascular major lower limb amputation (LLA). Methods: In this multicenter longitudinal observational study, the PA levels of adults who underwent dysvascular major LLA (n = 81) were assessed using the adapted Short Questionnaire to Assess Health-enhancing Physical Activity questionnaire (total hours, hours of moderate/vigorous, and metabolic equivalent of task-hours/week), at

KW - amputation

KW - exercise

KW - outcomes

KW - peripheral arterial disease

KW - physical activity

KW - amputatie

KW - beweging

KW - fysieke activiteit

KW - perifeer arterieel vaatlijden

KW - uitkomsten

U2 - 10.1016/j.jvs.2025.10.040

DO - 10.1016/j.jvs.2025.10.040

M3 - Article

SN - 0890-5096

VL - 83

SP - 866

EP - 878

JO - Annals of Vascular Surgery

JF - Annals of Vascular Surgery

IS - 3

ER -

Physical activity is associated with positive patient and clinical outcomes following dysvascular major lower limb amputation

Abstract

UN SDGs

Keywords

Research Focus Areas Hanze University of Applied Sciences * (mandatory by Hanze)

Research Focus Areas Research Centre or Centre of Expertise * (mandatory by Hanze)

Publinova themes

Access to Document

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Cite this