PhyloPat: an updated version of the phylogenetic pattern database contains gene neighborhood

Tim Hulsen, Peter M A Groenen, Jacob de Vlieg, Wynand Alkema

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Phylogenetic patterns show the presence or absence of certain genes in a set of full genomes derived from different species. They can also be used to determine sets of genes that occur only in certain evolutionary branches. Previously, we presented a database named PhyloPat which allows the complete Ensembl gene database to be queried using phylogenetic patterns. Here, we describe an updated version of PhyloPat which can be queried by an improved web server. We used a single linkage clustering algorithm to create 241,697 phylogenetic lineages, using all the orthologies provided by Ensembl v49. PhyloPat offers the possibility of querying with binary phylogenetic patterns or regular expressions, or through a phylogenetic tree of the 39 included species. Users can also input a list of Ensembl, EMBL, EntrezGene or HGNC IDs to check which phylogenetic lineage any gene belongs to. A link to the FatiGO web interface has been incorporated in the HTML output. For each gene, the surrounding genes on the chromosome, color coded according to their phylogenetic lineage can be viewed, as well as FASTA files of the peptide sequences of each lineage. Furthermore, lists of omnipresent, polypresent, oligopresent and anticorrelating genes have been included. PhyloPat is freely available at http://www.cmbi.ru.nl/phylopat.

Original languageEnglish
Pages (from-to)D731-D337
JournalNucleic acids research
Volume37
Issue numberDatabase issue
DOIs
Publication statusPublished - 2 Oct 2008

Keywords

  • algorithms
  • databases, genetic
  • evolution, molecular
  • genes
  • internet
  • phylogeny
  • user-computer interface

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