Person-Centered Integrated Care for Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Pim P Valentijn, Fernando Abdalla Pereira, Marinella Ruospo, Suetonia C Palmer, Jörgen Hegbrant, Christina W Sterner, Hubertus J M Vrijhoef, Dirk Ruwaard, Giovanni F M Strippoli

Research output: Contribution to journalArticleAcademicpeer-review


Background and objectives The effectiveness of person-centered integrated care strategies for CKD is uncertain. We conducted a systematic review and meta-analysis of randomized, controlled trials to assess the effect of person-centered integrated care for CKD. Design, setting, participants, & measurements We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (from inception to April of 2016), and selected randomized, controlled trials of person-centered integrated care interventions with a minimum follow-up of 3 months. Random-effects meta-analysis was used to assess the effect of person-centered integrated care. Results We included 14 eligible studies covering 4693 participants with a mean follow-up of 12 months. In moderate quality evidence, person-centered integrated care probably had no effect on all-cause mortality (relative risk [RR], 0.86; 95% confidence interval [95% CI], 0.68 to 1.08) or health-related quality of life (standardized mean difference, 0.02; 95% CI, 20.05 to 0.10). The effects on renal replacement therapy (RRT) (RR, 1.00; 95% CI, 0.65 to 1.55), serum creatinine levels (mean difference, 0.59 mg/dl; 95% CI, 20.38 to 0.36), and eGFR (mean difference, 1.51 ml/min per 1.73 m 2 ; 95% CI, 23.25 to 6.27) were very uncertain. Quantitative analysis suggested that person-centered integrated care interventions may reduce all-cause hospitalization (RR, 0.38; 95% CI, 0.15 to 0.95) and improve BP control (RR, 1.20; 95% CI, 1.00 to 1.44), although the certainty of the evidence was very low. Conclusions Person-centered integrated care may have little effect on mortality or quality of life. The effects on serum creatinine, eGFR, and RRT are uncertain, although person-centered integrated care may lead to fewer hospitalizations and improved BP control.
Original languageEnglish
Pages (from-to)375-386
Number of pages12
JournalClinical journal of the American Society of Nephrology : CJASN
Issue number3
Publication statusPublished - 9 Feb 2018
Externally publishedYes


  • blood pressure
  • cardiovascular diseases/mortality
  • creatinine/blood
  • delivery of health care, integrated
  • hospitalization
  • humans
  • patient-centered care
  • quality of life
  • randomized controlled trials as topic
  • renal insufficiency, chronic/physiopathology
  • renal replacement therapy


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