Perception of fatigue and quality of life in patients with COPD

Eileen Breslin, Cees van der Schans, Stephanie Breukink, Paula Meek, Kent Mercer, William Volz, Samuel Louie

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

INTRODUCTION: Although dyspnea is considered the primary activity-limiting symptom in patients with COPD, other symptoms, such as fatigue, are frequently reported. The purpose of this study was to determine the relationship between fatigue and pulmonary function, exercise tolerance, depression, and quality of life in patients with COPD.

METHODS: Forty-one patients (age = 62+/-8 years; FEV1 = 1.08+/-0.55 L; FEV1 percent predicted = 35.8+/-17%) from two sites participated in the study. Spirometric measures of pulmonary function were carried out in each patient. The Multidimensional Fatigue Inventory was used to measure five subscales of fatigue: general, physical and mental fatigue, reduction in activity, and reduction in motivation. The St. George Respiratory Questionnaire, used to measure quality of life, has three subscale dimensions (symptom, activity, and impact), as well as an overall or total quality of life score. Depression was measured with the Centers of Epidemiological Studies Depression Scale. In 19 patients, exercise tolerance was determined with the 6-min walking distance.

RESULTS: General fatigue correlated with FEV1, percent predicted (r = -0.32, p < 0.05), exercise tolerance (r = -0.55, p < 0.05), depression (r = 0.44, p < 0.01), and overall quality of life (r = 0.75, p < 0.01). Among the dimensions of fatigue, depression correlated with general and mental fatigue only. Physical dimensions of fatigue correlated with an increase in the severity of pulmonary impairment and reduction in exercise tolerance. The cognitive components of fatigue, such as reduction in motivation and mental fatigue, were not found to be highly correlated with physical dimensions of quality of life. All five subscales of fatigue showed relationship to the functional impact dimension and total impairment score in quality of life.

CONCLUSIONS: These data show a relationship between dimensions of fatigue and pulmonary function, exercise tolerance, and quality of life in COPD. Based on these results, fatigue is an important symptom requiring evaluation and management in patients with COPD. These data clarified also the relationship between depression and fatigue in this patient population.

Original languageEnglish
Pages (from-to)958-964
JournalChest
Volume114
Issue number4
DOIs
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • exercise tolerance
  • fatigue
  • lung diseases
  • middle aged
  • perception
  • respiratory function tests

Cite this

Breslin, E., van der Schans, C., Breukink, S., Meek, P., Mercer, K., Volz, W., & Louie, S. (1998). Perception of fatigue and quality of life in patients with COPD. Chest, 114(4), 958-964. https://doi.org/10.1378/chest.114.4.958
Breslin, Eileen ; van der Schans, Cees ; Breukink, Stephanie ; Meek, Paula ; Mercer, Kent ; Volz, William ; Louie, Samuel. / Perception of fatigue and quality of life in patients with COPD. In: Chest. 1998 ; Vol. 114, No. 4. pp. 958-964.
@article{aa3babb8b46045389e5790e4df125a0a,
title = "Perception of fatigue and quality of life in patients with COPD",
abstract = "INTRODUCTION: Although dyspnea is considered the primary activity-limiting symptom in patients with COPD, other symptoms, such as fatigue, are frequently reported. The purpose of this study was to determine the relationship between fatigue and pulmonary function, exercise tolerance, depression, and quality of life in patients with COPD.METHODS: Forty-one patients (age = 62+/-8 years; FEV1 = 1.08+/-0.55 L; FEV1 percent predicted = 35.8+/-17{\%}) from two sites participated in the study. Spirometric measures of pulmonary function were carried out in each patient. The Multidimensional Fatigue Inventory was used to measure five subscales of fatigue: general, physical and mental fatigue, reduction in activity, and reduction in motivation. The St. George Respiratory Questionnaire, used to measure quality of life, has three subscale dimensions (symptom, activity, and impact), as well as an overall or total quality of life score. Depression was measured with the Centers of Epidemiological Studies Depression Scale. In 19 patients, exercise tolerance was determined with the 6-min walking distance.RESULTS: General fatigue correlated with FEV1, percent predicted (r = -0.32, p < 0.05), exercise tolerance (r = -0.55, p < 0.05), depression (r = 0.44, p < 0.01), and overall quality of life (r = 0.75, p < 0.01). Among the dimensions of fatigue, depression correlated with general and mental fatigue only. Physical dimensions of fatigue correlated with an increase in the severity of pulmonary impairment and reduction in exercise tolerance. The cognitive components of fatigue, such as reduction in motivation and mental fatigue, were not found to be highly correlated with physical dimensions of quality of life. All five subscales of fatigue showed relationship to the functional impact dimension and total impairment score in quality of life.CONCLUSIONS: These data show a relationship between dimensions of fatigue and pulmonary function, exercise tolerance, and quality of life in COPD. Based on these results, fatigue is an important symptom requiring evaluation and management in patients with COPD. These data clarified also the relationship between depression and fatigue in this patient population.",
keywords = "exercise tolerance, fatigue, lung diseases, middle aged, perception, respiratory function tests, vermoeidheid, longziekten, middelbare leeftijd, perceptie, levenskwaliteit, ademhalingsfunctietesten",
author = "Eileen Breslin and {van der Schans}, Cees and Stephanie Breukink and Paula Meek and Kent Mercer and William Volz and Samuel Louie",
year = "1998",
doi = "10.1378/chest.114.4.958",
language = "English",
volume = "114",
pages = "958--964",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "4",

}

Breslin, E, van der Schans, C, Breukink, S, Meek, P, Mercer, K, Volz, W & Louie, S 1998, 'Perception of fatigue and quality of life in patients with COPD' Chest, vol. 114, no. 4, pp. 958-964. https://doi.org/10.1378/chest.114.4.958

Perception of fatigue and quality of life in patients with COPD. / Breslin, Eileen; van der Schans, Cees; Breukink, Stephanie; Meek, Paula; Mercer, Kent; Volz, William; Louie, Samuel.

In: Chest, Vol. 114, No. 4, 1998, p. 958-964.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Perception of fatigue and quality of life in patients with COPD

AU - Breslin, Eileen

AU - van der Schans, Cees

AU - Breukink, Stephanie

AU - Meek, Paula

AU - Mercer, Kent

AU - Volz, William

AU - Louie, Samuel

PY - 1998

Y1 - 1998

N2 - INTRODUCTION: Although dyspnea is considered the primary activity-limiting symptom in patients with COPD, other symptoms, such as fatigue, are frequently reported. The purpose of this study was to determine the relationship between fatigue and pulmonary function, exercise tolerance, depression, and quality of life in patients with COPD.METHODS: Forty-one patients (age = 62+/-8 years; FEV1 = 1.08+/-0.55 L; FEV1 percent predicted = 35.8+/-17%) from two sites participated in the study. Spirometric measures of pulmonary function were carried out in each patient. The Multidimensional Fatigue Inventory was used to measure five subscales of fatigue: general, physical and mental fatigue, reduction in activity, and reduction in motivation. The St. George Respiratory Questionnaire, used to measure quality of life, has three subscale dimensions (symptom, activity, and impact), as well as an overall or total quality of life score. Depression was measured with the Centers of Epidemiological Studies Depression Scale. In 19 patients, exercise tolerance was determined with the 6-min walking distance.RESULTS: General fatigue correlated with FEV1, percent predicted (r = -0.32, p < 0.05), exercise tolerance (r = -0.55, p < 0.05), depression (r = 0.44, p < 0.01), and overall quality of life (r = 0.75, p < 0.01). Among the dimensions of fatigue, depression correlated with general and mental fatigue only. Physical dimensions of fatigue correlated with an increase in the severity of pulmonary impairment and reduction in exercise tolerance. The cognitive components of fatigue, such as reduction in motivation and mental fatigue, were not found to be highly correlated with physical dimensions of quality of life. All five subscales of fatigue showed relationship to the functional impact dimension and total impairment score in quality of life.CONCLUSIONS: These data show a relationship between dimensions of fatigue and pulmonary function, exercise tolerance, and quality of life in COPD. Based on these results, fatigue is an important symptom requiring evaluation and management in patients with COPD. These data clarified also the relationship between depression and fatigue in this patient population.

AB - INTRODUCTION: Although dyspnea is considered the primary activity-limiting symptom in patients with COPD, other symptoms, such as fatigue, are frequently reported. The purpose of this study was to determine the relationship between fatigue and pulmonary function, exercise tolerance, depression, and quality of life in patients with COPD.METHODS: Forty-one patients (age = 62+/-8 years; FEV1 = 1.08+/-0.55 L; FEV1 percent predicted = 35.8+/-17%) from two sites participated in the study. Spirometric measures of pulmonary function were carried out in each patient. The Multidimensional Fatigue Inventory was used to measure five subscales of fatigue: general, physical and mental fatigue, reduction in activity, and reduction in motivation. The St. George Respiratory Questionnaire, used to measure quality of life, has three subscale dimensions (symptom, activity, and impact), as well as an overall or total quality of life score. Depression was measured with the Centers of Epidemiological Studies Depression Scale. In 19 patients, exercise tolerance was determined with the 6-min walking distance.RESULTS: General fatigue correlated with FEV1, percent predicted (r = -0.32, p < 0.05), exercise tolerance (r = -0.55, p < 0.05), depression (r = 0.44, p < 0.01), and overall quality of life (r = 0.75, p < 0.01). Among the dimensions of fatigue, depression correlated with general and mental fatigue only. Physical dimensions of fatigue correlated with an increase in the severity of pulmonary impairment and reduction in exercise tolerance. The cognitive components of fatigue, such as reduction in motivation and mental fatigue, were not found to be highly correlated with physical dimensions of quality of life. All five subscales of fatigue showed relationship to the functional impact dimension and total impairment score in quality of life.CONCLUSIONS: These data show a relationship between dimensions of fatigue and pulmonary function, exercise tolerance, and quality of life in COPD. Based on these results, fatigue is an important symptom requiring evaluation and management in patients with COPD. These data clarified also the relationship between depression and fatigue in this patient population.

KW - exercise tolerance

KW - fatigue

KW - lung diseases

KW - middle aged

KW - perception

KW - respiratory function tests

KW - vermoeidheid

KW - longziekten

KW - middelbare leeftijd

KW - perceptie

KW - levenskwaliteit

KW - ademhalingsfunctietesten

UR - http://www.mendeley.com/research/perception-fatigue-quality-life-patients-copd

U2 - 10.1378/chest.114.4.958

DO - 10.1378/chest.114.4.958

M3 - Article

VL - 114

SP - 958

EP - 964

JO - Chest

JF - Chest

SN - 0012-3692

IS - 4

ER -