Onset and transition of and recovery from adverse development: study methodology

Johanna T.W.  Wigman; Gerdina H.M. Pijnenborg; Richard Bruggeman; Maarten Vos; Anita Wessels; Inez  Oosterholt; Maaike Nauta; Renee Stelwagen; Lana Otto; Aniek Wester; Lex Wunderink; Esther Sportel; Nynke Boonstra

Onset and transition of and recovery from adverse development: study methodology

Johanna T.W. Wigman
, Gerdina H.M. Pijnenborg
, Richard Bruggeman
, Maarten Vos
, Anita Wessels
, Inez Oosterholt
, Maaike Nauta
, Renee Stelwagen
, Lana Otto
, Aniek Wester
, Lex Wunderink
, Esther Sportel
, Nynke Boonstra

Rehabilitation

Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)
Department of Clinical Psychology and Experimental Psychopathology
GGZ Drenthe
University of Groningen, University Medical Center Groningen, Rob Giel Research Center
University of Groningen, University Medical Center Groningen, University Center Psychiatry
Mediant Mental Health Organization
Accare
GGZ Friesland
NHL Stenden University of Applied Sciences

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential.

METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions.

RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.

Original language	English
Journal	Early Intervention in Psychiatry
Publication status	E-pub ahead of print - 5 Nov 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 03 Good Health and Well-being
SDG 04 Quality Education

Keywords

psychiatry
protocols
clinical staging
early intervention

Research Focus Areas Hanze University of Applied Sciences * (mandatory by Hanze)

Healthy Ageing

Research Focus Areas Research Centre or Centre of Expertise * (mandatory by Hanze)

Equality of opportunity and participation

Publinova themes

Other
Health
People and Society

Access to Document

https://doi.org/10.1111/eip.12882Licence: CC BY

Cite this

Wigman, J. T. W., Pijnenborg, G. H. M., Bruggeman, R., Vos, M., Wessels, A., Oosterholt, I., Nauta, M., Stelwagen, R., Otto, L., Wester, A., Wunderink , L., Sportel, E., & Boonstra, N. (2019). Onset and transition of and recovery from adverse development: study methodology. Early Intervention in Psychiatry. Advance online publication. https://doi.org/10.1111/eip.12882

@article{d76227cd97884d0b99653e81a3a1eb95,

title = "Onset and transition of and recovery from adverse development: study methodology",

abstract = "AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential. METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions. RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.",

keywords = "psychiatry, protocols, clinical staging, early intervention, psychiatrie, interventie",

author = "Wigman, \{Johanna T.W.\} and Pijnenborg, \{Gerdina H.M.\} and Richard Bruggeman and Maarten Vos and Anita Wessels and Inez Oosterholt and Maaike Nauta and Renee Stelwagen and Lana Otto and Aniek Wester and Lex Wunderink and Esther Sportel and Nynke Boonstra",

year = "2019",

month = nov,

day = "5",

language = "English",

journal = "Early Intervention in Psychiatry",

issn = "1751-7885",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Onset and transition of and recovery from adverse development

T2 - study methodology

AU - Wigman, Johanna T.W.

AU - Pijnenborg, Gerdina H.M.

AU - Bruggeman, Richard

AU - Vos, Maarten

AU - Wessels, Anita

AU - Oosterholt, Inez

AU - Nauta, Maaike

AU - Stelwagen, Renee

AU - Otto, Lana

AU - Wester, Aniek

AU - Wunderink , Lex

AU - Sportel, Esther

AU - Boonstra, Nynke

PY - 2019/11/5

Y1 - 2019/11/5

N2 - AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential. METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions. RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.

AB - AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential. METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions. RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.

KW - psychiatry

KW - protocols

KW - clinical staging

KW - early intervention

KW - psychiatrie

KW - interventie

M3 - Article

SN - 1751-7885

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

ER -

Onset and transition of and recovery from adverse development: study methodology

Abstract

UN SDGs

Keywords

Research Focus Areas Hanze University of Applied Sciences * (mandatory by Hanze)

Research Focus Areas Research Centre or Centre of Expertise * (mandatory by Hanze)

Publinova themes

Access to Document

Other files and links

Fingerprint

Cite this