Onset and transition of and recovery from adverse development: study methodology

Johanna T.W. Wigman, Gerdina H.M. Pijnenborg, Richard Bruggeman, Maarten Vos, Anita Wessels, Inez Oosterholt, Maaike Nauta, Renee Stelwagen, Lana Otto, Aniek Wester, Lex Wunderink , Esther Sportel, Nynke Boonstra

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential.

METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions.

RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.
Original languageEnglish
JournalEarly intervention in psychiatry
Publication statusE-pub ahead of print - 5 Nov 2019

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Psychotic Disorders
Netherlands
Psychiatry
Comorbidity
Cohort Studies
Quality of Life

Keywords

  • psychiatry
  • protocols
  • clinical staging
  • early intervention

Cite this

Wigman, J. T. W., Pijnenborg, G. H. M., Bruggeman, R., Vos, M., Wessels, A., Oosterholt, I., ... Boonstra, N. (2019). Onset and transition of and recovery from adverse development: study methodology. Early intervention in psychiatry.
Wigman, Johanna T.W. ; Pijnenborg, Gerdina H.M. ; Bruggeman, Richard ; Vos, Maarten ; Wessels, Anita ; Oosterholt, Inez ; Nauta, Maaike ; Stelwagen, Renee ; Otto, Lana ; Wester, Aniek ; Wunderink , Lex ; Sportel, Esther ; Boonstra, Nynke. / Onset and transition of and recovery from adverse development : study methodology. In: Early intervention in psychiatry. 2019.
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abstract = "AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential.METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions.RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.",
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Wigman, JTW, Pijnenborg, GHM, Bruggeman, R, Vos, M, Wessels, A, Oosterholt, I, Nauta, M, Stelwagen, R, Otto, L, Wester, A, Wunderink , L, Sportel, E & Boonstra, N 2019, 'Onset and transition of and recovery from adverse development: study methodology', Early intervention in psychiatry.

Onset and transition of and recovery from adverse development : study methodology. / Wigman, Johanna T.W. ; Pijnenborg, Gerdina H.M.; Bruggeman, Richard; Vos, Maarten; Wessels, Anita; Oosterholt, Inez ; Nauta, Maaike; Stelwagen, Renee; Otto, Lana; Wester, Aniek; Wunderink , Lex; Sportel, Esther; Boonstra, Nynke.

In: Early intervention in psychiatry, 05.11.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Onset and transition of and recovery from adverse development

T2 - study methodology

AU - Wigman, Johanna T.W.

AU - Pijnenborg, Gerdina H.M.

AU - Bruggeman, Richard

AU - Vos, Maarten

AU - Wessels, Anita

AU - Oosterholt, Inez

AU - Nauta, Maaike

AU - Stelwagen, Renee

AU - Otto, Lana

AU - Wester, Aniek

AU - Wunderink , Lex

AU - Sportel, Esther

AU - Boonstra, Nynke

PY - 2019/11/5

Y1 - 2019/11/5

N2 - AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential.METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions.RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.

AB - AIM: Early intervention programs for first-episode psychosis have led to the awareness that the period before onset of a first episode is important in light of early intervention. This has induced a focus on the so-called 'at risk mental state' (ARMS). Individuals with ARMS are at increased risk for later psychotic disorder, but also for other psychiatric disorders as well as poor psychosocial functioning. Thus, adequate detection and treatment of ARMS is essential.METHODS: Since 2018, screening for and treatment of ARMS is recommended standard care in the Netherlands. Implementation is still ongoing. We initiated a naturalistic long-term cohort study of ARMS individuals, the onset and transition of and recovery from adverse development (OnTheROAD) study, with the aim to monitor course and outcome of symptoms and psychosocial functioning over time, as well as patterns of comorbidity and associations with factors of risk and resilience. To this end, participants complete a broad battery of instruments at baseline and yearly follow-up assessments up to 3 years. Outcome is defined in terms of symptom severity level, functioning and quality of life. In particular, we aim to investigate the impact of negative symptoms as part of the ARMS concept. Results from this study can aid in refining the existing ARMS criteria, understanding the developmental course of ARMS and investigating the hypothesized pluripotentiality in outcome of ARMS. New knowledge may inform the further development of specialized early interventions.RESULTS AND CONCLUSIONS: In this article, we describe the rationale, outline and set-up of OnTheROAD.

KW - psychiatry

KW - protocols

KW - clinical staging

KW - early intervention

KW - psychiatrie

KW - interventie

M3 - Article

JO - Early intervention in psychiatry

JF - Early intervention in psychiatry

SN - 1751-7885

ER -

Wigman JTW, Pijnenborg GHM, Bruggeman R, Vos M, Wessels A, Oosterholt I et al. Onset and transition of and recovery from adverse development: study methodology. Early intervention in psychiatry. 2019 Nov 5.