Novel compositions and methods for trehalose phospholipids

Ildiko van Rhijn (Inventor), Adriaan Minnaard (Inventor), Branch Moody (Inventor), Tan-Yun Cheng (Inventor), Jeffrey Buter (Inventor)

Research output: PatentAcademic


Provided herein are compositions of trehalose phospholipids and uses thereof, e.g., compounds and compositions comprising 6,6′-diphosphatidyltrehalose (diPT) and analogs thereof with modifications of the diPT chemical scaffold, that bind and agonize Mincle, and the use thereof as adjuvants.
Original languageEnglish
Patent numberUS20220119438A1
Filing date8/01/20
Publication statusPublished - 21 Apr 2022
Externally publishedYes


  • vaccine
  • lipids
  • salmonella


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