TY - JOUR
T1 - Maternal pre-pregnancy overweight and neonatal gut bacterial colonization are associated with cognitive development and gut microbiota composition in pre-school-age offspring
AU - Guzzardi, Maria Angela
AU - Ederveen, Thomas H.A.
AU - Rizzo, Francesca
AU - Weisz, Alessandro
AU - Collado, Maria Carmen
AU - Muratori, Filippo
AU - Gross, Gabriele
AU - Alkema, Wynand
AU - Iozzo, Patricia
PY - 2021/12/21
Y1 - 2021/12/21
N2 - Maternal gestational obesity is a risk factor for offspring's neurodevelopment and later neuro-cognitive disorders. Altered gut microbiota composition has been found in patients with neurocognitive disorders, and in relation to maternal metabolic health. We explored the associations between gut microbiota and cognitive development during infancy, and their link with maternal obesity. In groups of children from the Pisa birth Cohort (PISAC), we analysed faecal microbiota composition by 16S rRNA marker gene sequencing of first-pass meconium samples and of faecal samples collected at age 3, 6, 12, 24, 36 months, and its relationship with maternal gestational obesity or diabetes, and with cognitive development, as measured from 6 to 60 months of age by the Griffith's Mental Development Scales. Gut microbiota composition in the first phases of life is dominated by Bifidobacteria (Actinobacteria phylum), with contribution of Escherichia/Shigella and Klebsiella genera (Proteobacteria phylum), whereas Firmicutes beco
AB - Maternal gestational obesity is a risk factor for offspring's neurodevelopment and later neuro-cognitive disorders. Altered gut microbiota composition has been found in patients with neurocognitive disorders, and in relation to maternal metabolic health. We explored the associations between gut microbiota and cognitive development during infancy, and their link with maternal obesity. In groups of children from the Pisa birth Cohort (PISAC), we analysed faecal microbiota composition by 16S rRNA marker gene sequencing of first-pass meconium samples and of faecal samples collected at age 3, 6, 12, 24, 36 months, and its relationship with maternal gestational obesity or diabetes, and with cognitive development, as measured from 6 to 60 months of age by the Griffith's Mental Development Scales. Gut microbiota composition in the first phases of life is dominated by Bifidobacteria (Actinobacteria phylum), with contribution of Escherichia/Shigella and Klebsiella genera (Proteobacteria phylum), whereas Firmicutes beco
KW - children cognition
KW - cognitive development
KW - early programming
KW - gut microbiota
KW - maternal obesity
KW - cognitie van kinderen
KW - cognitieve ontwikkeling
KW - vroege programmering
KW - darmmicrobiota
KW - zwaarlijvigheid van de moeder
U2 - 10.1016/j.bbi.2021.12.009
DO - 10.1016/j.bbi.2021.12.009
M3 - Article
C2 - 34920092
VL - 100
SP - 311
EP - 320
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -