Lewis-acid catalysis of carbon carbon bond forming reactions in water

Jan B.F.N. Engberts, Ben L. Feringa, Erik Keller, Sijbren Otto

Research output: Contribution to journalArticleAcademicpeer-review


In this article, we review the recent progress that has been made in the field of Lewis-acid catalysis of carbon carbon-bond-forming reactions in aqueous solution. Since water hampers the hard hard interactions between the catalyst and the reactant, it often complicates catalysis. However, once coordination has taken place, water can have beneficial effects on rates and selectivities of Lewis acid catalysed Diels Alder reactions, aldol reactions, allylation reactions, Barbier and Mannich type reactions as well as Michael additions.
Original languageEnglish
Pages (from-to)457-464
JournalRecueil des travaux chimiques des Pays-Bas : journal of the Royal Netherlands Chemical Society
Issue number11-12
Publication statusPublished - 1 Jan 1996


  • lewis-acid catalysis
  • reactions in water


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