Keyphrases
Nitro
100%
Acylation
100%
β-lactam Antibiotics
100%
Penicillin Acylase
100%
Deacylation
100%
Acyl-coenzyme A
71%
Hydrolysis
57%
4-aminobenzoic Acid
57%
Nucleophile
42%
Benzoic Acid
42%
Ampicillin
28%
Rate-limiting Step
28%
Kcat
28%
Inverse Isotope Effect
28%
Lactams
14%
Steady State
14%
Penicillin
14%
Semi-synthetic
14%
High Affinity
14%
Mechanistic Aspects
14%
High Viscosity
14%
Glycerol
14%
Rate Measurement
14%
Kinetic Aspects
14%
Fractionation Factor
14%
Molar Fraction
14%
Deuterium Isotope Effect
14%
Isotope Effect
14%
Acid-base Mechanism
14%
Binding Experiment
14%
Transition State
14%
D 2O
14%
Penicillin G
14%
Via Formation
14%
Stopped Flow
14%
6-Aminopenicillanic Acid
14%
Flow Experiment
14%
General Acid
14%
Kinetic Isotope Effect
14%
Kinetic Constants
14%
Proton Inventory
14%
Proton
14%
Chemistry
Beta Lactam Antibiotic Agent
100%
Benzoic Acid
100%
Deacylation
100%
Penicillin
100%
Acylation
100%
Enzymatic Hydrolysis
57%
Nucleophile
42%
formation
42%
Kcat
28%
Kinetic Isotope Effect
28%
Ampicillin
28%
Transition State
14%
6-Aminopenicillanic Acid
14%
Lactam
14%
Base
14%
Pharmacology, Toxicology and Pharmaceutical Science
Beta Lactam Antibiotic
100%
Amidase
100%
Penicillin Derivative
100%
Aminobenzoic Acid
100%
Nucleophile
75%
Benzoic Acid
75%
Ampicillin
50%
Lactam
25%
6 Aminopenicillanic Acid
25%
Penicillin G
25%
Deuterium
25%
Base
25%
Biochemistry, Genetics and Molecular Biology