TY - JOUR
T1 - Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
AU - Lindeboom, Lucas
AU - Roumans, Kay H M
AU - Veeraiah, Pandichelvam
AU - Remie, Carlijn M E
AU - Phielix, Esther
AU - Havekes, Bas
AU - Bruls, Yvonne M H
AU - Brouwers, Martijn C G J
AU - Ståhlman, Marcus
AU - Alssema, Marjan
AU - Peters, Harry P F
AU - de Mutsert, Renée
AU - Staels, Bart
AU - Taskinen, Marja-Riitta
AU - Borén, Jan
AU - Schrauwen, Patrick
AU - Schrauwen-Hinderling, Vera B
PY - 2020/4/20
Y1 - 2020/4/20
N2 - Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.
AB - Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity.
KW - adipose tissue
KW - adult
KW - aged
KW - cross-sectional studies
KW - diabetes mellitus, type 2/metabolism
KW - fatty acids/metabolism
KW - female
KW - humans
KW - insulin resistance/physiology
KW - lipids
KW - lipogenesis/physiology
KW - liver/diagnostic imaging
KW - male
KW - middle aged
KW - non-alcoholic fatty liver disease/metabolism
KW - triglycerides/metabolism
KW - vetweefsel
KW - volwassene
KW - ouder
KW - cross-sectionele studies
KW - diabetes mellitus, type 2/metabolisme
KW - vetzuren/metabolisme
KW - vrouwelijk
KW - mensen
KW - insulineresistentie/fysiologie
KW - lipiden
KW - lipogenese/fysiologie
KW - lever/diagnostische beeldvorming
KW - mannelijk
KW - middelbare leeftijd
KW - niet-alcoholische leververvetting/metabolisme
KW - triglyceriden/metabolisme
U2 - 10.1038/s41467-020-15684-0
DO - 10.1038/s41467-020-15684-0
M3 - Article
C2 - 32312974
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
M1 - 1891
ER -