Fast selection of miRNA candidates based on large-scale pre-computed MFE sets of randomized sequences.

Research output: Contribution to journalArticleAcademicpeer-review

18 Downloads (Pure)

Abstract

Small RNAs are important regulators of genome function, yet their prediction in genomes is still a major computational challenge. Statistical analyses of pre-miRNA sequences indicated that their 2D structure tends to have a minimal free energy (MFE) significantly lower than MFE values of equivalently randomized sequences with the same nucleotide composition, in contrast to other classes of non-coding RNA. The computation of many MFEs is, however, too intensive to allow for genome-wide screenings.
Original languageEnglish
Number of pages10
JournalBMC research notes
Publication statusPublished - 13 Jan 2014

    Fingerprint

Keywords

  • energy
  • grid computing
  • molecular techniques

Cite this