Fast selection of miRNA candidates based on large-scale pre-computed MFE sets of randomized sequences.

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Small RNAs are important regulators of genome function, yet their prediction in genomes is still a major computational challenge. Statistical analyses of pre-miRNA sequences indicated that their 2D structure tends to have a minimal free energy (MFE) significantly lower than MFE values of equivalently randomized sequences with the same nucleotide composition, in contrast to other classes of non-coding RNA. The computation of many MFEs is, however, too intensive to allow for genome-wide screenings.
Original languageEnglish
Number of pages10
JournalBMC research notes
Publication statusPublished - 13 Jan 2014



  • energy
  • grid computing
  • molecular techniques

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