Effect of nocturnal haemodialysis on body composition

Karin Ipema, R Westerhuis, Cees van der Schans, P.E. de Jong, C.E. Gaillard, Wim Krijnen, R.H. Slart, C.F. Franssen

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Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Therefore, we studied whether 1 year of NHD is associated with a change in body composition. Methods: Whole-body composition using dual-energy X-ray absorptiometry (DEXA) and normalised protein catabolic rate (nPCR) were measured in 11 adult patients before and 1 year after the transition from CHD (12 h dialysis/week) to NHD (28-48 h dialysis/week). Similar measurements were performed in a matched control group of 13 patients who stayed on CHD. Differences between groups were analysed with linear mixed models. Results: At baseline, nPCR, total mass, fat-free mass, and fat mass did not differ significantly between the CHD and NHD groups. nPCR increased in the NHD group (from 0.96 ± 0.23 to 1.12 ± 0.20 g/kg/day; p = 0.027) whereas it was stable in the CHD group (0.93 ± 0.21 at baseline and 0.87 ± 0.09 g/kg/day at 1 year, n.s.). The change in nPCR differed significantly between the two groups (p = 0.027). We observed no significant differences in the course of total mass, fat-free mass, and fat mass during the 1-year observation period between the NHD and CHD groups. Conclusions: One year of NHD had no significant effect on body composition in comparison with CHD, despite a significantly higher protein intake in patients on NHD.
Original languageEnglish
Pages (from-to)171-177
JournalNephron clinical practice
Issue number1-2
Publication statusPublished - 2014



  • nocturnal haemodialysis
  • malnutrition

Cite this

Ipema, K., Westerhuis, R., van der Schans, C., de Jong, P. E., Gaillard, C. E., Krijnen, W., ... Franssen, C. F. (2014). Effect of nocturnal haemodialysis on body composition. Nephron clinical practice, 128(1-2), 171-177.