Effect of nocturnal haemodialysis on body composition

Karin Ipema, R Westerhuis, Cees van der Schans, P.E. de Jong, C.E. Gaillard, Wim Krijnen, R.H. Slart, C.F. Franssen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Therefore, we studied whether 1 year of NHD is associated with a change in body composition. Methods: Whole-body composition using dual-energy X-ray absorptiometry (DEXA) and normalised protein catabolic rate (nPCR) were measured in 11 adult patients before and 1 year after the transition from CHD (12 h dialysis/week) to NHD (28-48 h dialysis/week). Similar measurements were performed in a matched control group of 13 patients who stayed on CHD. Differences between groups were analysed with linear mixed models. Results: At baseline, nPCR, total mass, fat-free mass, and fat mass did not differ significantly between the CHD and NHD groups. nPCR increased in the NHD group (from 0.96 ± 0.23 to 1.12 ± 0.20 g/kg/day; p = 0.027) whereas it was stable in the CHD group (0.93 ± 0.21 at baseline and 0.87 ± 0.09 g/kg/day at 1 year, n.s.). The change in nPCR differed significantly between the two groups (p = 0.027). We observed no significant differences in the course of total mass, fat-free mass, and fat mass during the 1-year observation period between the NHD and CHD groups. Conclusions: One year of NHD had no significant effect on body composition in comparison with CHD, despite a significantly higher protein intake in patients on NHD.
Original languageEnglish
Pages (from-to)171-177
JournalNephron clinical practice
Volume128
Issue number1-2
Publication statusPublished - 2014

Keywords

  • nocturnal haemodialysis
  • malnutrition

Cite this

Ipema, K., Westerhuis, R., van der Schans, C., de Jong, P. E., Gaillard, C. E., Krijnen, W., ... Franssen, C. F. (2014). Effect of nocturnal haemodialysis on body composition. Nephron clinical practice, 128(1-2), 171-177.
Ipema, Karin ; Westerhuis, R ; van der Schans, Cees ; de Jong, P.E. ; Gaillard, C.E. ; Krijnen, Wim ; Slart, R.H. ; Franssen, C.F. . / Effect of nocturnal haemodialysis on body composition. In: Nephron clinical practice. 2014 ; Vol. 128, No. 1-2. pp. 171-177.
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abstract = "Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Therefore, we studied whether 1 year of NHD is associated with a change in body composition. Methods: Whole-body composition using dual-energy X-ray absorptiometry (DEXA) and normalised protein catabolic rate (nPCR) were measured in 11 adult patients before and 1 year after the transition from CHD (12 h dialysis/week) to NHD (28-48 h dialysis/week). Similar measurements were performed in a matched control group of 13 patients who stayed on CHD. Differences between groups were analysed with linear mixed models. Results: At baseline, nPCR, total mass, fat-free mass, and fat mass did not differ significantly between the CHD and NHD groups. nPCR increased in the NHD group (from 0.96 ± 0.23 to 1.12 ± 0.20 g/kg/day; p = 0.027) whereas it was stable in the CHD group (0.93 ± 0.21 at baseline and 0.87 ± 0.09 g/kg/day at 1 year, n.s.). The change in nPCR differed significantly between the two groups (p = 0.027). We observed no significant differences in the course of total mass, fat-free mass, and fat mass during the 1-year observation period between the NHD and CHD groups. Conclusions: One year of NHD had no significant effect on body composition in comparison with CHD, despite a significantly higher protein intake in patients on NHD.",
keywords = "nocturnal haemodialysis, malnutrition, nachtelijke hemodialyse, nhd, ondervoeding",
author = "Karin Ipema and R Westerhuis and {van der Schans}, Cees and {de Jong}, P.E. and C.E. Gaillard and Wim Krijnen and R.H. Slart and C.F. Franssen",
year = "2014",
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Ipema, K, Westerhuis, R, van der Schans, C, de Jong, PE, Gaillard, CE, Krijnen, W, Slart, RH & Franssen, CF 2014, 'Effect of nocturnal haemodialysis on body composition' Nephron clinical practice, vol. 128, no. 1-2, pp. 171-177.

Effect of nocturnal haemodialysis on body composition. / Ipema, Karin; Westerhuis, R; van der Schans, Cees; de Jong, P.E.; Gaillard, C.E.; Krijnen, Wim; Slart, R.H.; Franssen, C.F. .

In: Nephron clinical practice, Vol. 128, No. 1-2, 2014, p. 171-177.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effect of nocturnal haemodialysis on body composition

AU - Ipema, Karin

AU - Westerhuis, R

AU - van der Schans, Cees

AU - de Jong, P.E.

AU - Gaillard, C.E.

AU - Krijnen, Wim

AU - Slart, R.H.

AU - Franssen, C.F.

PY - 2014

Y1 - 2014

N2 - Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Therefore, we studied whether 1 year of NHD is associated with a change in body composition. Methods: Whole-body composition using dual-energy X-ray absorptiometry (DEXA) and normalised protein catabolic rate (nPCR) were measured in 11 adult patients before and 1 year after the transition from CHD (12 h dialysis/week) to NHD (28-48 h dialysis/week). Similar measurements were performed in a matched control group of 13 patients who stayed on CHD. Differences between groups were analysed with linear mixed models. Results: At baseline, nPCR, total mass, fat-free mass, and fat mass did not differ significantly between the CHD and NHD groups. nPCR increased in the NHD group (from 0.96 ± 0.23 to 1.12 ± 0.20 g/kg/day; p = 0.027) whereas it was stable in the CHD group (0.93 ± 0.21 at baseline and 0.87 ± 0.09 g/kg/day at 1 year, n.s.). The change in nPCR differed significantly between the two groups (p = 0.027). We observed no significant differences in the course of total mass, fat-free mass, and fat mass during the 1-year observation period between the NHD and CHD groups. Conclusions: One year of NHD had no significant effect on body composition in comparison with CHD, despite a significantly higher protein intake in patients on NHD.

AB - Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Therefore, we studied whether 1 year of NHD is associated with a change in body composition. Methods: Whole-body composition using dual-energy X-ray absorptiometry (DEXA) and normalised protein catabolic rate (nPCR) were measured in 11 adult patients before and 1 year after the transition from CHD (12 h dialysis/week) to NHD (28-48 h dialysis/week). Similar measurements were performed in a matched control group of 13 patients who stayed on CHD. Differences between groups were analysed with linear mixed models. Results: At baseline, nPCR, total mass, fat-free mass, and fat mass did not differ significantly between the CHD and NHD groups. nPCR increased in the NHD group (from 0.96 ± 0.23 to 1.12 ± 0.20 g/kg/day; p = 0.027) whereas it was stable in the CHD group (0.93 ± 0.21 at baseline and 0.87 ± 0.09 g/kg/day at 1 year, n.s.). The change in nPCR differed significantly between the two groups (p = 0.027). We observed no significant differences in the course of total mass, fat-free mass, and fat mass during the 1-year observation period between the NHD and CHD groups. Conclusions: One year of NHD had no significant effect on body composition in comparison with CHD, despite a significantly higher protein intake in patients on NHD.

KW - nocturnal haemodialysis

KW - malnutrition

KW - nachtelijke hemodialyse

KW - nhd

KW - ondervoeding

M3 - Article

VL - 128

SP - 171

EP - 177

JO - Nephron clinical practice

JF - Nephron clinical practice

SN - 1660-2110

IS - 1-2

ER -

Ipema K, Westerhuis R, van der Schans C, de Jong PE, Gaillard CE, Krijnen W et al. Effect of nocturnal haemodialysis on body composition. Nephron clinical practice. 2014;128(1-2):171-177.