Cost study of dermal substitutes and topical negative pressure in the surgical treatment of burns

TOPSKIN Study Group

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: A recently performed randomised controlled trial investigated the clinical effectiveness of dermal substitutes (DS) and split skin grafts (SSG) in combination with topical negative pressure (TNP) in the surgical treatment of burn wounds. In the current study, medical and non-medical costs were investigated, to comprehensively assess the benefits of this new treatment.

METHODS: The primary outcome was mean total costs of the four treatment strategies: SSG with or without DS, and with or without TNP. Costs were studied from a societal perspective. Findings were evaluated in light of the clinical effects on scar elasticity.

RESULTS: Eighty-six patients were included. Twelve months post-operatively, highest elasticity was measured in scars treated with DS and TNP (p=0.027). The initial cost price of treatment with DS and TNP was €2912 compared to treatment with SSG alone €1703 (p<0.001). However, mean total costs per patient did not differ significantly between groups (range €29097-€43774).

DISCUSSION: Costs of the interventional treatment contributed maximal 7% to the total costs and total costs varied widely within and between groups, but were not significantly different. Therefore, in the selection of the most optimal type of surgical intervention, cost considerations should not play an important role.

Original languageEnglish
Pages (from-to)388-396
Number of pages9
JournalBurns : journal of the International Society for Burn Injuries
Issue number3
Publication statusPublished - 1 May 2014
Externally publishedYes


  • adolescent
  • Adult
  • 80 and over
  • burns/economics
  • costs and cost analysis
  • female
  • health care costs
  • humans
  • male
  • middle aged
  • negative-pressure wound therapy/economics
  • skin transplantation/economics
  • skin, artificial/economics
  • young adult


Dive into the research topics of 'Cost study of dermal substitutes and topical negative pressure in the surgical treatment of burns'. Together they form a unique fingerprint.

Cite this