Comparison of whole body versus thoracic bioimpedance in relation to ultrafiltration volume and systolic blood pressure during hemodialysis

Melanie K Schoutteten, Lucas Lindeboom, Astrid Brys, Dorien Lanssens, Christophe J P Smeets, Hélène De Cannière, Bart De Moor, Jacques Peeters, Line Heylen, Chris Van Hoof, Willemijn Groenendaal, Jeroen P Kooman, Pieter M Vandervoort

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In contrast to whole body bioimpedance, which estimates fluid status at a single point in time, thoracic bioimpedance applied by a wearable device could enable continuous measurements. However, clinical experience with thoracic bioimpedance in patients on dialysis is limited. To test the reproducibility of whole body and thoracic bioimpedance measurements and to compare their relationship with hemodynamic changes during hemodialysis, these parameters were measured pre- and end-dialysis in 54 patients during two sessions. The resistance from both bioimpedance techniques was moderately reproducible between two dialysis sessions (intraclass correlations of pre- to end-dialysis whole body and thoracic resistance between session 1 and 2 were 0.711 [0.58-0.8] and 0.723 [0.6-0.81], respectively). There was a very high to high correlation between changes in ultrafiltration volume and changes in whole body thoracic resistance. Changes in systolic blood pressure negatively correlated to both bioimpedance techniques. Although the relationship between changes in ultrafiltration volume and changes in resistance was stronger for whole body bioimpedance, the relationship with changes in blood pressure was at least comparable for thoracic measurements. These results suggest that thoracic bioimpedance, measured by a wearable device, may serve as an interesting alternative to whole body measurements for continuous hemodynamic monitoring during hemodialysis.NEW & NOTEWORTHY We examined the role of whole body and thoracic bioimpedance in hemodynamic changes during hemodialysis. Whole body and thoracic bioimpedance signals were strongly related to ultrafiltration volume and moderately, negatively, to changes in blood pressure. This work supports the further development of a wearable device measuring thoracic bioimpedance longitudinally in patients on hemodialysis. As such, it may serve as an innovative tool for continuous hemodynamic monitoring during hemodialysis in hospital or in a home-based setting.

Original languageEnglish
Pages (from-to)1330-1338
Number of pages9
JournalJournal of applied physiology (Bethesda, Md. : 1985)
Volume135
Issue number6
DOIs
Publication statusPublished - 28 Nov 2023
Externally publishedYes

Keywords

  • humans
  • ultrafiltration/methods
  • blood pressure
  • reproducibility of results
  • renal dialysis
  • electric impedance

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