Cancer-related fatigue: predictors and effects of rehabilitation

Ellen van Weert, Josette Hoekstra-Weebers, Renée Otter, Klaas Postema, Robbert Sanderman, Cees van der Schans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: The aims of the study were to examine the effects of a multidimensional rehabilitation program on cancer-related fatigue, to examine concurrent predictors of fatigue, and to investigate whether change in fatigue over time was associated with change in predictors.

METHODS:

SAMPLE: 72 cancer survivors with different diagnoses.

SETTING: rehabilitation center.

INTERVENTION: 15-week rehabilitation program.

MEASURES: Fatigue (Multidimensional Fatigue Inventory), demographic and disease/treatment-related variables, body composition (bioelectrical impedance), exercise capacity (symptom-limited bicycle ergometry), muscle force (handheld dynamometry), physical and psychological symptom distress (Rotterdam Symptom Check List), experienced physical and psychological functioning (RAND-36), and self-efficacy (General-Self-Efficacy Scale, Dutch version). Measurements were performed before (T0) and after rehabilitation (T1).

RESULTS: At T1 (n = 56), significant improvements in fatigue were found, with effect sizes varying from -0.35 to -0.78. At T0, the different dimensions of fatigue were predicted by different physical and psychological variables. Explained variance of change in fatigue varied from 42%-58% and was associated with pre-existing fatigue and with change in physical functioning, role functioning due to physical problems, psychological functioning, and physical symptoms distress.

CONCLUSIONS: Within this selected group of patients we found that (a) rehabilitation is effective in reducing fatigue, (b) both physical and psychological parameters predicted different dimensions of fatigue at baseline, and (c) change in fatigue was mainly associated with change in physical parameters.

Original languageEnglish
Pages (from-to)184-196
JournalThe oncologist
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2006

Keywords

  • academic medical centers
  • adult
  • analysis of variance
  • exercise
  • fatigue
  • females
  • humans
  • males
  • mental fatigue
  • middle aged
  • neoplasms
  • netherlands
  • psychiatric status rating scales
  • registries
  • rehabilitation centers
  • self efficacy
  • survivors
  • time factors
  • treatment outcome

Cite this

van Weert, E., Hoekstra-Weebers, J., Otter, R., Postema, K., Sanderman, R., & van der Schans, C. (2006). Cancer-related fatigue: predictors and effects of rehabilitation. The oncologist, 11(2), 184-196. https://doi.org/10.1634/theoncologist.11-2-184
van Weert, Ellen ; Hoekstra-Weebers, Josette ; Otter, Renée ; Postema, Klaas ; Sanderman, Robbert ; van der Schans, Cees. / Cancer-related fatigue : predictors and effects of rehabilitation. In: The oncologist. 2006 ; Vol. 11, No. 2. pp. 184-196.
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title = "Cancer-related fatigue: predictors and effects of rehabilitation",
abstract = "BACKGROUND: The aims of the study were to examine the effects of a multidimensional rehabilitation program on cancer-related fatigue, to examine concurrent predictors of fatigue, and to investigate whether change in fatigue over time was associated with change in predictors.METHODS: SAMPLE: 72 cancer survivors with different diagnoses.SETTING: rehabilitation center.INTERVENTION: 15-week rehabilitation program.MEASURES: Fatigue (Multidimensional Fatigue Inventory), demographic and disease/treatment-related variables, body composition (bioelectrical impedance), exercise capacity (symptom-limited bicycle ergometry), muscle force (handheld dynamometry), physical and psychological symptom distress (Rotterdam Symptom Check List), experienced physical and psychological functioning (RAND-36), and self-efficacy (General-Self-Efficacy Scale, Dutch version). Measurements were performed before (T0) and after rehabilitation (T1).RESULTS: At T1 (n = 56), significant improvements in fatigue were found, with effect sizes varying from -0.35 to -0.78. At T0, the different dimensions of fatigue were predicted by different physical and psychological variables. Explained variance of change in fatigue varied from 42{\%}-58{\%} and was associated with pre-existing fatigue and with change in physical functioning, role functioning due to physical problems, psychological functioning, and physical symptoms distress.CONCLUSIONS: Within this selected group of patients we found that (a) rehabilitation is effective in reducing fatigue, (b) both physical and psychological parameters predicted different dimensions of fatigue at baseline, and (c) change in fatigue was mainly associated with change in physical parameters.",
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van Weert, E, Hoekstra-Weebers, J, Otter, R, Postema, K, Sanderman, R & van der Schans, C 2006, 'Cancer-related fatigue: predictors and effects of rehabilitation' The oncologist, vol. 11, no. 2, pp. 184-196. https://doi.org/10.1634/theoncologist.11-2-184

Cancer-related fatigue : predictors and effects of rehabilitation. / van Weert, Ellen; Hoekstra-Weebers, Josette; Otter, Renée; Postema, Klaas; Sanderman, Robbert; van der Schans, Cees.

In: The oncologist, Vol. 11, No. 2, 02.2006, p. 184-196.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cancer-related fatigue

T2 - predictors and effects of rehabilitation

AU - van Weert, Ellen

AU - Hoekstra-Weebers, Josette

AU - Otter, Renée

AU - Postema, Klaas

AU - Sanderman, Robbert

AU - van der Schans, Cees

PY - 2006/2

Y1 - 2006/2

N2 - BACKGROUND: The aims of the study were to examine the effects of a multidimensional rehabilitation program on cancer-related fatigue, to examine concurrent predictors of fatigue, and to investigate whether change in fatigue over time was associated with change in predictors.METHODS: SAMPLE: 72 cancer survivors with different diagnoses.SETTING: rehabilitation center.INTERVENTION: 15-week rehabilitation program.MEASURES: Fatigue (Multidimensional Fatigue Inventory), demographic and disease/treatment-related variables, body composition (bioelectrical impedance), exercise capacity (symptom-limited bicycle ergometry), muscle force (handheld dynamometry), physical and psychological symptom distress (Rotterdam Symptom Check List), experienced physical and psychological functioning (RAND-36), and self-efficacy (General-Self-Efficacy Scale, Dutch version). Measurements were performed before (T0) and after rehabilitation (T1).RESULTS: At T1 (n = 56), significant improvements in fatigue were found, with effect sizes varying from -0.35 to -0.78. At T0, the different dimensions of fatigue were predicted by different physical and psychological variables. Explained variance of change in fatigue varied from 42%-58% and was associated with pre-existing fatigue and with change in physical functioning, role functioning due to physical problems, psychological functioning, and physical symptoms distress.CONCLUSIONS: Within this selected group of patients we found that (a) rehabilitation is effective in reducing fatigue, (b) both physical and psychological parameters predicted different dimensions of fatigue at baseline, and (c) change in fatigue was mainly associated with change in physical parameters.

AB - BACKGROUND: The aims of the study were to examine the effects of a multidimensional rehabilitation program on cancer-related fatigue, to examine concurrent predictors of fatigue, and to investigate whether change in fatigue over time was associated with change in predictors.METHODS: SAMPLE: 72 cancer survivors with different diagnoses.SETTING: rehabilitation center.INTERVENTION: 15-week rehabilitation program.MEASURES: Fatigue (Multidimensional Fatigue Inventory), demographic and disease/treatment-related variables, body composition (bioelectrical impedance), exercise capacity (symptom-limited bicycle ergometry), muscle force (handheld dynamometry), physical and psychological symptom distress (Rotterdam Symptom Check List), experienced physical and psychological functioning (RAND-36), and self-efficacy (General-Self-Efficacy Scale, Dutch version). Measurements were performed before (T0) and after rehabilitation (T1).RESULTS: At T1 (n = 56), significant improvements in fatigue were found, with effect sizes varying from -0.35 to -0.78. At T0, the different dimensions of fatigue were predicted by different physical and psychological variables. Explained variance of change in fatigue varied from 42%-58% and was associated with pre-existing fatigue and with change in physical functioning, role functioning due to physical problems, psychological functioning, and physical symptoms distress.CONCLUSIONS: Within this selected group of patients we found that (a) rehabilitation is effective in reducing fatigue, (b) both physical and psychological parameters predicted different dimensions of fatigue at baseline, and (c) change in fatigue was mainly associated with change in physical parameters.

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KW - analysis of variance

KW - exercise

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KW - middle aged

KW - neoplasms

KW - netherlands

KW - psychiatric status rating scales

KW - registries

KW - rehabilitation centers

KW - self efficacy

KW - survivors

KW - time factors

KW - treatment outcome

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KW - volwassene

KW - oud

KW - variantieanalyse

KW - oefening

KW - vermoeidheid

KW - mensen

KW - mentale vermoeidheid

KW - middelbaar

KW - neoplasma's

KW - nederland

KW - psychiatrische status notering

KW - revalidatie centra

KW - overlevers

KW - tijdsfactoren

KW - behandelingsresultaten

U2 - 10.1634/theoncologist.11-2-184

DO - 10.1634/theoncologist.11-2-184

M3 - Article

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EP - 196

JO - The oncologist

JF - The oncologist

SN - 1083-7159

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