Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form

Carlos A. Martinez, Renzo Meijer, Gerard Metselaar, Gerlof Kruithof, Curtis Moore, Pei Pei Kung, Erik Keller

Research output: Contribution to journalArticleAcademicpeer-review


An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. The described synthesis was used to manufacture 6 kg of the title compound and can also be employed to produce the corresponding (1R)-enantiomer. © 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2408-2413
JournalTetrahedron: asymmetry
Issue number19
Publication statusPublished - 7 Oct 2010


  • biotransformation
  • biocatalysis
  • PLE


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