Autoantibody profiles in systemic sclerosis: a comparison of diagnostic tests

Wynand Alkema; Hans J P M Koenen; Brigit E. Kersten; Charlotte Kaffa; Jaqueline W Nannenberg-Koops; Jan G. M. C.  Damoiseux

Autoantibody profiles in systemic sclerosis: a comparison of diagnostic tests

Wynand Alkema, Hans J P M Koenen, Brigit E. Kersten, Charlotte Kaffa, Jaqueline W Nannenberg-Koops, Jan G. M. C. Damoiseux

Radboud UMC

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, standardization in autoimmune serology is lacking, which may have a negative impact on the added value of autoantibodies in diagnosis and prognosis of SSc. In this paper we describe the comparison of commercially available diagnostic assays for the detection of SSc-associated autoantibodies and explored the coexistence of multiple SSc-associated autoantibodies within patients.

Original language	English
Pages (from-to)	148-155
Number of pages	7
Journal	Autoimmunity
Volume	54
Issue number	3
Publication status	Published - 5 Apr 2021

Keywords

systemic sclerosis
diagnostic assays
antibodies

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https://www.tandfonline.com/doi/figure/10.1080/08916934.2021.1907842?scroll=top&needAccess=true

3 Article
1 Blogs and web publications

Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study
Lemmers, J., van Caam, A., Kersten, B. E., van den Ende, C., Knaapen, H., van Dijk, A., Hagmolen of Ten Have, W., van den Hoogen, F., Koenen, H. J. P. M., van Leuven, S., Alkema, W., Smeets, R. L. & Vonk, M. C., 22 May 2023, (E-pub ahead of print) In: Journal of Scleroderma and Related Disorders. 8, 3, p. 221-230 9 p., 3.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods
van Beuningen, N., Alkema, S., Hijlkema, N., Ulfhake, B., Frias, R., Ritskes-Hoitinga, M. & Alkema, W., 21 Oct 2023, In: Alternatives to Laboratory Animals. 51, 6, p. 376-386 10 p.
Research output: Contribution to journal › Article › Academic › peer-review
Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients
Alkema, W., He, X., Kaffa, C., Joosten, I., Smeets, R. L., Koenen, H. J. P. M., Mulder, M. L. M., van den Reek, J. M. P. A., Urbano, P. C. M., Wang, X., van Cranenbroek, B., van Rijssen, E., Van Den Hoogen, F. H. J., de Jong, E. M. G. .. J. & Wenink, M. H., 12 Oct 2021, In: International Journal of Molecular Sciences. 22, 10 p., 10990.
Research output: Contribution to journal › Article › Academic › peer-review

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Data-onderzoek legt patronen bloot in het belang van gezondheid
Alkema, W.
7/11/23
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'Productontwikkelaars moeten zich verdiepen in de mogelijkheden van Artificial intelligence'
Alkema, W.
17/09/23
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Cite this

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title = "Autoantibody profiles in systemic sclerosis: a comparison of diagnostic tests",

abstract = "Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, standardization in autoimmune serology is lacking, which may have a negative impact on the added value of autoantibodies in diagnosis and prognosis of SSc. In this paper we describe the comparison of commercially available diagnostic assays for the detection of SSc-associated autoantibodies and explored the coexistence of multiple SSc-associated autoantibodies within patients.",

keywords = "antistoffen, systemische sclerose, systemic sclerosis, diagnostic assays, antibodies",

author = "Wynand Alkema and Koenen, {Hans J P M} and Kersten, {Brigit E.} and Charlotte Kaffa and Nannenberg-Koops, {Jaqueline W} and Damoiseux, {Jan G. M. C.}",

year = "2021",

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language = "English",

volume = "54",

pages = "148--155",

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publisher = "Taylor and Francis Ltd.",

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T1 - Autoantibody profiles in systemic sclerosis

T2 - a comparison of diagnostic tests

AU - Alkema, Wynand

AU - Koenen, Hans J P M

AU - Kersten, Brigit E.

AU - Kaffa, Charlotte

AU - Nannenberg-Koops, Jaqueline W

AU - Damoiseux, Jan G. M. C.

PY - 2021/4/5

Y1 - 2021/4/5

N2 - Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, standardization in autoimmune serology is lacking, which may have a negative impact on the added value of autoantibodies in diagnosis and prognosis of SSc. In this paper we describe the comparison of commercially available diagnostic assays for the detection of SSc-associated autoantibodies and explored the coexistence of multiple SSc-associated autoantibodies within patients.

AB - Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, standardization in autoimmune serology is lacking, which may have a negative impact on the added value of autoantibodies in diagnosis and prognosis of SSc. In this paper we describe the comparison of commercially available diagnostic assays for the detection of SSc-associated autoantibodies and explored the coexistence of multiple SSc-associated autoantibodies within patients.

KW - antistoffen

KW - systemische sclerose

KW - systemic sclerosis

KW - diagnostic assays

KW - antibodies

M3 - Article

SN - 1607-842X

VL - 54

SP - 148

EP - 155

JO - Autoimmunity

JF - Autoimmunity

IS - 3

ER -

Autoantibody profiles in systemic sclerosis: a comparison of diagnostic tests

Abstract

Keywords

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Research output

Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study

The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods

Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients

Press/Media

Data-onderzoek legt patronen bloot in het belang van gezondheid

'Productontwikkelaars moeten zich verdiepen in de mogelijkheden van Artificial intelligence'

Cite this