Autoantibody profiles in systemic sclerosis: a comparison of diagnostic tests

Wynand Alkema, Hans J P M Koenen, Brigit E. Kersten, Charlotte Kaffa, Jaqueline W Nannenberg-Koops, Jan G. M. C. Damoiseux

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, standardization in autoimmune serology is lacking, which may have a negative impact on the added value of autoantibodies in diagnosis and prognosis of SSc. In this paper we describe the comparison of commercially available diagnostic assays for the detection of SSc-associated autoantibodies and explored the coexistence of multiple SSc-associated autoantibodies within patients.
    Original languageEnglish
    Pages (from-to)148-155
    Number of pages7
    JournalAutoimmunity
    Volume54
    Issue number3
    Publication statusPublished - 5 Apr 2021

    Keywords

    • systemic sclerosis
    • diagnostic assays
    • antibodies

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