Animal energy budgets affect the kinetics of xenobiotics

S.A.L.M. Kooijman, R.J.F. van Haren

Research output: Contribution to journalArticleAcademicpeer-review


On the basis of a model for energy budgets, which includes the dynamics of stored energy, a model has been proposed for the kinetics of non-metabolized xenobiotic compounds, which may be lipophilic. The surface area coupled uptake is via food and/or water through the aqueous fraction of the animal. The partitioning to non-aqueous structural body mass and to stored materials (i.e. lipids, carbohydrates and proteins) is taken instantaneously. The result is a simple first order kinetics with variable coefficients. The bioconcentration factor has been evaluated. Model predictions have been tested against data from the litera
Original languageEnglish
Pages (from-to)681-693
Issue number4-5
Publication statusPublished - 1 Jan 1990


  • xenobiotics


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