Abstract
Background: Decline in physical activity and functioning is commonly observed in the older population and might be associated with biomarkers such as Advanced Glycation End-products (AGEs). AGEs contribute to age-related decline in the function of cells and tissues in normal aging and have been found to be associated with motor function decline. The aim of this study is to investigate the association between the levels of AGEs, as assessed by skin autofluorescence, and the amount of physical activity and loss of physical functioning in older participants.
Methods: Cross-sectional data of 5,624 participants aged 65 years and older from the Lifelines cohort study was used. Linear regression analyses were utilized to study associations between skin autofluorescence/AGE-levels (AGE reader), the number of physically active days (SQUASH), and physical functioning (RAND-36), respectively. A logistic regression analysis was used to study associations between AGE-levels and the compliance with the Dutch physical activity guidelines (SQUASH).
Results: A statistical significant association between AGE levels and the number of physically active days (β = -0.21, 95% CI: -0.35 to -0.07, P = .004), physical functioning (β = -1.60, 95% CI: -2.64 to -0.54, P = .003), and compliance with the Dutch physical activity guidelines (OR = 0.76, 95% CI: 0.62 to 0.94, P = .010) was revealed.
Conclusions: This study indicates that high AGE levels may be a contributing factor as well as a biomarker for lower levels of physical activity and functioning in the older population.
| Original language | English |
|---|---|
| Pages (from-to) | 1545-1551 |
| Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
| Volume | 73 |
| Issue number | 11 |
| Early online date | 28 Apr 2018 |
| DOIs | |
| Publication status | Published - 8 Oct 2018 |
Keywords
- physical activities
- elderly people
Cite this
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Advanced glycation end-products are associated with physical activity and physical functioning in the older population. / Drenth, Hans; Zuidema, Sytse U; Krijnen, Wim P; Bautmans, Ivan; Smit, Andries J; Schans, Cees van der; Hobbelen, Hans.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 73, No. 11, 08.10.2018, p. 1545-1551.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Advanced glycation end-products are associated with physical activity and physical functioning in the older population
AU - Drenth, Hans
AU - Zuidema, Sytse U
AU - Krijnen, Wim P
AU - Bautmans, Ivan
AU - Smit, Andries J
AU - Schans, Cees van der
AU - Hobbelen, Hans
PY - 2018/10/8
Y1 - 2018/10/8
N2 - Background: Decline in physical activity and functioning is commonly observed in the older population and might be associated with biomarkers such as Advanced Glycation End-products (AGEs). AGEs contribute to age-related decline in the function of cells and tissues in normal aging and have been found to be associated with motor function decline. The aim of this study is to investigate the association between the levels of AGEs, as assessed by skin autofluorescence, and the amount of physical activity and loss of physical functioning in older participants.Methods: Cross-sectional data of 5,624 participants aged 65 years and older from the Lifelines cohort study was used. Linear regression analyses were utilized to study associations between skin autofluorescence/AGE-levels (AGE reader), the number of physically active days (SQUASH), and physical functioning (RAND-36), respectively. A logistic regression analysis was used to study associations between AGE-levels and the compliance with the Dutch physical activity guidelines (SQUASH).Results: A statistical significant association between AGE levels and the number of physically active days (β = -0.21, 95% CI: -0.35 to -0.07, P = .004), physical functioning (β = -1.60, 95% CI: -2.64 to -0.54, P = .003), and compliance with the Dutch physical activity guidelines (OR = 0.76, 95% CI: 0.62 to 0.94, P = .010) was revealed.Conclusions: This study indicates that high AGE levels may be a contributing factor as well as a biomarker for lower levels of physical activity and functioning in the older population.
AB - Background: Decline in physical activity and functioning is commonly observed in the older population and might be associated with biomarkers such as Advanced Glycation End-products (AGEs). AGEs contribute to age-related decline in the function of cells and tissues in normal aging and have been found to be associated with motor function decline. The aim of this study is to investigate the association between the levels of AGEs, as assessed by skin autofluorescence, and the amount of physical activity and loss of physical functioning in older participants.Methods: Cross-sectional data of 5,624 participants aged 65 years and older from the Lifelines cohort study was used. Linear regression analyses were utilized to study associations between skin autofluorescence/AGE-levels (AGE reader), the number of physically active days (SQUASH), and physical functioning (RAND-36), respectively. A logistic regression analysis was used to study associations between AGE-levels and the compliance with the Dutch physical activity guidelines (SQUASH).Results: A statistical significant association between AGE levels and the number of physically active days (β = -0.21, 95% CI: -0.35 to -0.07, P = .004), physical functioning (β = -1.60, 95% CI: -2.64 to -0.54, P = .003), and compliance with the Dutch physical activity guidelines (OR = 0.76, 95% CI: 0.62 to 0.94, P = .010) was revealed.Conclusions: This study indicates that high AGE levels may be a contributing factor as well as a biomarker for lower levels of physical activity and functioning in the older population.
KW - physical activities
KW - elderly people
KW - bewegen (activiteit)
KW - ouderen
U2 - 10.1093/gerona/gly108
DO - 10.1093/gerona/gly108
M3 - Article
VL - 73
SP - 1545
EP - 1551
JO - The journals of gerontology. Series A, Biological sciences and medical sciences
JF - The journals of gerontology. Series A, Biological sciences and medical sciences
SN - 1079-5006
IS - 11
ER -