[1,4]-Benzodiazepines as Vasopressin V2 Receptor Antagonists -...

Erik Keller (Inventor), Ann MEULEMANS (Inventor), Karel LAVRIJSEN (Inventor), Marina COOLS (Inventor), Igor, Alexnadrovich MEZINE, (Inventor), Leen THIELEMANS (Inventor), Maarten VAN GEFFEN (Inventor)

Research output: PatentProfessional


The invention relates to a novel class of [1,4]-benzodiazepine derivatives, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds. Other aspects of the invention are directed to the use of said [1,4]-benzodiazepine derivatives in therapy based on the capability of said compounds to interfere with the binding of the peptide hormone, vasopressin, to its receptors. In particular as vasopressin V2 receptor antagonists and therefore useful for treating involving increased vascular resistance, cardiac insufficiency, and water retention.
Original languageEnglish
Patent number11036204
Filing date23/09/10
Publication statusPublished - 31 Mar 2011


  • benzodiazepine derivatives
  • patents
  • use
  • medicine


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