Photo of Erik Keller
1993 …2019

Research activity per year

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Personal profile

Personal profile

Erik Keller (11-03-1970) obtained his PhD in Organic chemistry under the supervision of Prof. dr. Ben L. Feringa in 1998 working on “Catalytic enantioselective conjugate addition reactions: with a focus on water”. Afterwards he started his career in R&D in organic chemistry at Syncom bv where he worked in different positions and was responsible for various development programs ranging from early stage medicinal chemistry to scale up and development and synthesis of complex (chiral) building blocks, novell chemical entities and stable isotope labeled compounds. Later he joined Lab Ofichem as head of R&D, where he was responsible for the development and implementation of production methods for novel active pharmaceutical ingredients.

Early 2020 joined the Kenniscentrum Biobased Economy where he ao is working on the upcycling of polyhydroxyalkanoate monomers and oligomers for pharmaceutical, (functional) food and polymer recycling. ‘

 

His main interests are on the development of sustainable green life science implementations.

 

Publications

1,3-Dipolar cycloadditions to 5-methoxy-2(5H)-furanone

Erik Keller, Ben de Lange, Minze T. Rispens, Ben L. Feringa, Tetrahedron 1993, 49, 8899.

Publications

Asymmetric 1,3-dipolar cycloadditions to 5-(R)-menthyloxy-2(5H)-furanone

Minze T. Rispens, Erik Keller, Ben de Lange, Robert W.J. Zijlstra, Ben L. Feringa, Tetrahedron Asymmetry 1994, 5, 607.

Publications

Synthesis of (11C)methyl magnesium iodide and its application to the introduction of(11C)-N-tert-butyl groups and (11C)-sec-alcohols

Philip H. Elsinga, Erik Keller, Tjibbe J. de Groot, Gerben M. Visser, Willem Vaalburg, Applied radiation and isotopes 1995, 46, 227.

Publications

Ytterbium triflate catalyzed Michael additions of b-ketoesters in water

Erik Keller, Ben L. Feringa, Tetrahedron Letters 1996, 7, 1879.

Publications

Lewis-acid catalysis of carbon carbon bond forming reactions in water

Jan B.N.F. Engberts, Ben L. Feringa, Erik Keller, Sijbren Otto, Recueil des TravauxChimiques des Pays-Bas 1996, 115, 457.

Publications

Highly efficient ytterbium triflate catalyzed Michael additions of a-nitroesters in water

Erik Keller, Ben L. Feringa, Synlett 1997, 842.

Publications

Catalytic enantioselective Michael addition reactions of a-nitroesters to a,b-unsaturated ketones

Erik Keller, Nora Veldman, Anthony L. Spek, Ben L, Feringa, Tetrahedron Asymmetry 1997, 8, 3403.

Publications

Unexpected enhancement of enantioselectivity in copper (II) catalyzed conjugate addition of diethylzinc to cyclic enones with novel TADDOL phosphorus amidite ligands

Erik Keller, Jochen Maurer, Robert Naasz, Thomas Schader, Auke Meetsma, Ben L. Feringa Tetrahedron Asymmetry 1998,9, 2094

Publications

(±)-6,6'-Dinitro-1,1'-binaphthyl 2,2'-diacetate

Auke Meetsma, Erik Keller, Ben L.Feringa, Acta Cryst. 1999, C55, 450.

Publications

Catalytic Enantioselective Annulations via 1,4-Addition-Aldol Cyclization of Functionalized Organozinc Reagents

Robert Naasz, Leggy A. Arnold, Mauro Pineschi, Erik Keller, Ben L. Feringa, J. Am. Chem. Soc. 1999, 121, 1104.

Publications

Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form

Carlos A. Martinez, Erik Keller, Renzo Meijer, Gerard Metselaar, Gerlof Kruithof, Curtis Moore and Pei-Pei Kung  Tetrahedron Asymmetry  2010, 21,  2408.

Intellectual Property

(1,4)-Benzodiazepines vasopressin V2 receptor antagonisys

Leen Thielemans. Maarten van Geffen, Ann Meulemans, Marina Cools, Erik Keller, Karel Lavrijsen GB 1013708.1.

Intellectual Property

Process to extract and purify delta-9-tetrahydrocannabinol

Changoer, L.; Loo C.H.M. van der; Keller, E. WO 2016/179247 A1.

Publications

Rapid chemoenzymatic route to glutamate transporter inhibitor L-TFB-TBOA and related amino acids

Haigen Fu,  Sabry H. H. Younes,  Mohammad Saifuddin,  Pieter G. Tepper,  Jielin Zhang,  Erik Keller,  André Heeres,  Wiktor Szymanski  and  Gerrit J. Poelarend Org. Biomol. Chem., 2017,15, 2341-2344.

Intellectual Property

 Methods for providing highly pure palmitoylethanolamide (PEA), pure PEA preparationsm and uses thereof

Dabous, S.J.; Keller E. WO2019066644.

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